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Bufalin Induces Lung Cancer Cell Apoptosis via the Inhibition of PI3K/Akt Pathway
  • Z. Zhu, Hongzhi Sun, +4 authors Y. Liu
  • Chemistry, Medicine
  • International journal of molecular sciences
  • 14 February 2012
Bufalin is a class of toxic steroids which could induce the differentiation and apoptosis of leukemia cells, and induce the apoptosis of gastric, colon and breast cancer cells. However, theExpand
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RETRACTED ARTICLE: Nrdp1 inhibits growth of colorectal cancer cells by nuclear retention of p27
The molecular mechanism underlying the proliferation of colorectal cancer (CRC) cells is not completely understood. Here, we found that the level of neuregulin receptor degradation protein-1 (Nrdp1)Expand
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miR-224 is Critical for Celastrol-Induced Inhibition of Migration and Invasion of Hepatocellular Carcinoma Cells
Background/Aims: The molecular mechanisms of celastrol on hepatocellular carcinoma (HCC) cells migration and invasion ability is the major problem that prompted the study. Methods: We first evaluatedExpand
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Arctigenin Attenuates Lipopolysaccharide-Induced Acute Lung Injury in Rats
Arctigenin (ATG) has been reported to possess anti-inflammatory properties. However, the effects of ATG on lipopolysaccharide (LPS)-induced acute lung injury (ALI) remains not well understood. In theExpand
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Bufalin Induces the Apoptosis of Acute Promyelocytic Leukemia Cells via the Downregulation of Survivin Expression
Background and Aims: Bufalin is a cardiotonic steroid isolated from the Chinese toad venom preparation Chan’su and has been shown to induce leukemia cell differentiation and apoptosis under certainExpand
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Extracellular HSP70/HSP70-PCs Promote Epithelial-Mesenchymal Transition of Hepatocarcinoma Cells
Background Extracellular heat shock protein 70 and peptide complexes (eHSP70/HSP70-PCs) regulate a variety of biological behaviors in tumor cells. Whether eHSP70/HSP70-PCs are involved in theExpand
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RRM2 is a potential prognostic biomarker with functional significance in glioma
Glioma is one of the most common brain tumors, suggesting the importance of investigating the molecular mechanism of gliomas. We studied the roles of Ribonucleotide Reductase Regulatory Subunit M2Expand
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Long noncoding RNA Mirt2 upregulates USP10 expression to suppress hepatic steatosis by sponging miR-34a-5p.
Non-alcoholic fatty liver disease (NAFLD) is always characterized by hepatic steatosis and insulin resistance. Dysregulated long noncoding RNAs regulate pathogenesis of NAFLD. However, the role ofExpand
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HCRP1 is downregulated in non-small cell lung cancer and regulates proliferation, invasion, and drug resistance
HCRP1 has been reported to have tumor suppressive function. However, its expression pattern and function in human non-small cell lung cancer (NSCLC) remain obscure. This study aims to exploreExpand
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ASF1B promotes cervical cancer progression through stabilization of CDK9
Cervical cancer (CC) is one of the most deadly cancers in women, its current treatments still result in poor outcomes and developing the novel targets and therapeutic strategies are urgently needed.Expand