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People with Rett syndrome (RTT) have breathing instability in addition to other neuropathological manifestations. The breathing disturbances contribute to the high incidence of unexplained death and abnormal brain development. However, the cellular mechanisms underlying the breathing abnormalities remain unclear. To test the hypothesis that the central(More)
42 Catecholaminergic neurons in the locus coeruleus (LC) play a role in the ventilatory 43 response to hypercapnia. Here we show evidence for the involvement of TRP channels. We 44 found that the input resistance was reduced during an exposure to 8% CO 2 in ~35% LC neurons 45 in mouse brain slices, accompanied with depolarization and higher firing activity.(More)
Catecholaminergic neurons in the locus coeruleus (LC) play a role in the ventilatory response to hypercapnia. Here, we show evidence for the involvement of transient receptor potential (TRP) channels. We found that the input resistance was reduced during an exposure to 8% CO(2) in ~35% LC neurons in mouse brain slices, accompanied by depolarization and(More)
Involvement of TRP channels in the CO 2 chemosensitivity of locus coeruleus neurons.gic neurons in the locus coeruleus (LC) play a role in the ventilatory response to hypercapnia. Here, we show evidence for the involvement of transient receptor potential (TRP) channels. We found that the input resistance was reduced during an exposure to 8% CO 2 in ϳ35% LC(More)
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