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People with Rett syndrome (RTT) have breathing instability in addition to other neuropathological manifestations. The breathing disturbances contribute to the high incidence of unexplained death and abnormal brain development. However, the cellular mechanisms underlying the breathing abnormalities remain unclear. To test the hypothesis that the central(More)
Sepsis is a severe medical condition causing a large number of deaths worldwide. Recent studies indicate that the septic susceptibility is attributable to the vascular ATP-sensitive K(+) (K(ATP)) channel. However, the mechanisms underlying the channel modulation in sepsis are still unclear. Here we show evidence for the modulation of vascular K(ATP) channel(More)
Cui N, Zhang X, Tadepalli JS, Yu L, Gai H, Petit J, Pamulapati RT, Jin X, Jiang C. Involvement of TRP channels in the CO2 chemosensitivity of locus coeruleus neurons. J Neurophysiol 105: 2791–2801, 2011. First published March 23, 2011; doi:10.1152/jn.00759.2010.—Catecholaminergic neurons in the locus coeruleus (LC) play a role in the ventilatory response to(More)
4 Ningren Cui*, Xiaoli Zhang*, Jyothirmayee S. Tadepalli, Lei Yu, Hongyu Gai, James Petit, 5 Ravi T. Pamulapati, Xin Jin and Chun Jiang 6 7 Department of Biology, Georgia State University, 100 Piedmont Avenue, Suite 495 8 P.O. Box 4010, Atlanta, GA 30302 9 10 11 12 13 Running head: TRP channels in neuronal CO2 chemosensitivity 14 15 Number of text pages: 28(More)
In this paper, the results of EPR, VIS and enzyme activity show that alkaline phophatase from calf intrest directly interacted with additional Cu(II). The added Cu(II) enter into A site of active sites of AKP which decrease enzyme activity. With increase of pH value, the decrease in the intensity of the Cu(II) EPR signal and the change of place signal in(More)
In this paper, we studied the directly interaction between nuclease Pl and CuCl2 in aqueous solution by visible absorption spectra. As a result, the zinc ion in the active site of nuclease Pl can be replaced by additional Cu(II). At the the same time, Cu(II) entered into the active site of enzyme forming the correspondent derivatives of "Cu(II)-Pl". The(More)
Catecholaminergic neurons in the locus coeruleus (LC) play a role in the ventilatory response to hypercapnia. Here, we show evidence for the involvement of transient receptor potential (TRP) channels. We found that the input resistance was reduced during an exposure to 8% CO(2) in ~35% LC neurons in mouse brain slices, accompanied by depolarization and(More)
In this report the pharmacological action of Spicatus was studied. The results insicated that it had diureric, antibiotic and anti-inflammatory effects, yet had Iittle toxic side-effect. It had significant inhibitory effect on crofon oil-caused mice ear swell. It also had marked diuretic effect in orcinary rats, but had Iittie effect on uric pH the rats. It(More)
The effect of changing the amount of external added Co(trp)n and pH values on the interaction of Cu2Zn2 SOD with organic metal compound (Cobalt(II)-Tryptophane) have been studied by means of ICP, VIS and measurement of enzyme activity. It has found that in aqueous solution, there exists a direct interaction of the metal ions of the active center in the(More)
In this paper, the method of reconstitution was used to investigate the interaction between metalloenzymes (containing Zn (II) and metal ions. Electron paramagnetic resonance(EPR), visible spectrum (Vis) and enzyme activity assay have been employed to study the direct interactions between aminoacylase (ACY) and Cu(II) ions added in aqueous solution. The(More)
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