Hongyan Zhao

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Polymorphisms of the vitamin D receptor gene (VDR) have been shown to be associated with several complex diseases, including osteoporosis, but the mechanisms are unknown and study results have been inconsistent. We therefore determined sequence variation across the major relevant parts of VDR, including construction of linkage disequilibrium blocks and(More)
UNLABELLED After reported associations of variations in the BMP-2 gene with osteoporosis in small populations, we studied the association of the BMP-2 gene polymorphisms Ser37Ala and Arg190Ser with osteoporosis in 6353 men and women from the Rotterdam Study. We did not observe an association of these variants with BMD, bone loss, hip structural analysis(More)
Recently, a number of studies have demonstrated the potential beneficial role for novel anti-diabetic GLP-1 receptor agonists (GLP-1RAs) in the skeleton metabolism in diabetic rodents and patients. In this study, we evaluated the impacts of the synthetic GLP-1RA Liraglutide on bone mass and quality in osteoporotic rats induced by ovariectomy (OVX) but(More)
Lumbar drainage (LD) is considered as a simple and effective procedure for the treatment of intracerebral hemorrhage with ventricular involvement. However, cerebrospinal fluid overdrainage and hypovolemia due to LD could induce severe fatal complications, which include transtentorial herniation and infratentorial hemorrhage. Here, we describe a 63-year-old(More)
This paper proposes a new method for designing a developable surface by constructing a surface pencil passing through a given curve, which is quite in accord with the practice in industry design and manufacture. By utilizing the Frenet trihedron frame, we derive the necessary and sufficient conditions to construct a developable surface through a given(More)
BACKGROUND Previous studies have shown that a low dose of propofol IV bolus had a beneficial effect on intrathecal morphine-induced pruritus in humans. However, its exact mechanism has not been fully understood. In this study, we hypothesized that propofol relieved intrathecal morphine-induced pruritus in rats by upregulating the expression of cannabinoid-1(More)
This paper proposes an approach to design the surface pencil with specified parametric representations from a given geodesic. The surface was considered as a combination of the marching-scale functions and the Frenet trihedron frame, for which some necessary and sufficient conditions must be met. This paper simplifies those conditions, and represents the(More)
in malnourished gastric cancer. However, recently we checked our data again and found there was an obvious difference between experimental and control groups in the tumor status at the beginning of the trial. In addition, the sample size was not calculated, which might be not enough to reach a significant power. Thus, the trial might be biased and we, the(More)