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PURPOSE To quantify measurement uncertainties of fractional anisotropy, mean diffusivity, and principal eigenvector orientations in human diffusion tensor imaging (DTI) data acquired with common clinical protocols using a wild bootstrap analysis, and to establish optimal scan protocols for clinical DTI acquisitions. MATERIALS AND METHODS A group of 13(More)
BACKGROUND Alzheimer's disease (AD) is associated with changes in cerebral white matter (WM), but the functional significance of such findings is not yet established. We hypothesized that diffusion tensor imaging (DTI) might reveal links between regional WM changes and specific neuropsychologically and psychophysically defined impairments in early AD. (More)
OBJECTIVE Alzheimer's disease (AD) is a serious neurodegenerative disorder characterized by deficits of working memory, attention, language and many other cognitive functions. Although different stages of the disease are relatively well characterized by clinical criteria, stage-specific pathological changes in the brain remain relatively poorly understood,(More)
Diffusion kurtosis imaging (DKI) is a new diffusion magnetic resonance imaging (MRI) technique to go beyond the shortages of conventional diffusion tensor imaging (DTI) from the assumption that water diffuse in biological tissue is Gaussian. Kurtosis is used to measure the deviation of water diffusion from Gaussian model, which is called non-Gaussian, in(More)
OBJECTIVE To evaluate non-Gaussian diffusion changes of the whole-brain and its correlation with cognitive performance in patients with early Alzheimer's disease (AD), using diffusion kurtosis imaging (DKI). METHODS Twenty-six patients with early AD and twenty-six normal controls underwent diffusion imaging. Seven parametric maps were calculated from(More)
To explore the changes of glutamate-glutamine (Glx) and gamma-aminobutyric acid (GABA) in the brain in normal old age and cognitive impairment using magnetic resonance spectroscopy (MRS). Seventeen normal young controls (NYC), 15 normal elderly controls (NEC), 21 patients with mild cognitive impairment (MCI) and 17 with Alzheimer disease (AD) patients were(More)
Normal aging is typically characterized by abnormal resting-state functional connectivity (FC), including decreasing connectivity within networks and increasing connectivity between networks, under the assumption that the FC over the scan time was stationary. In fact, the resting-state FC has been shown in recent years to vary over time even within minutes,(More)
PURPOSES To compare the characteristics of DCE-MRI between metastatic and benign lymph nodes (LNs). To explore the effect of sizes of LNs on the value of Ktrans, Ve and iAUC. MATERIALS AND METHODS Metastatic and benign LNs were retrospectively analyzed. Chi-square test and two sample t-test were applied to TICs and parameters. One factor covariance(More)
OBJECTIVE To determine the value of resting-state functional magnetic resonance imaging (RS-fMRI) based on the local analysis methods regional homogeneity (ReHo), amplitude of low-frequency fluctuations (ALFF), and fractional ALFF (fALFF), for detecting epileptogenic zones (EZs). METHODS A total of 42 consecutive patients with focal epilepsy were(More)