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Insulin-like growth factors (IGFs), IGF receptors, and IGF-binding proteins: roles in skeletal muscle growth and differentiation.
The insulin-like growth factor (IGF) signaling pathway consists of multiple IGF ligands, IGF receptors, and IGF-binding proteins (IGFBPs). Studies in a variety of animal and cellular systems suggest… Expand
IGFBP-5 regulates muscle cell differentiation by binding to IGF-II and switching on the IGF-II auto-regulation loop
IGF-II stimulates both mitogenesis and myogenesis through its binding and activation of the IGF-I receptor (IGF-IR). How this growth factor pathway promotes these two opposite cellular responses is… Expand
Hypoxia converts the myogenic action of insulin-like growth factors into mitogenic action by differentially regulating multiple signaling pathways
- Hongxia Ren, D. Accili, C. Duan
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 15 March 2010
Insulin-like growth factors (IGFs) stimulate myoblast proliferation and differentiation. It remains elusive how these mutually exclusive cellular responses are elicited by the same growth factor.… Expand
Differential regulation of IGF-I and IGF-II gene expression in skeletal muscle cells
- Shuang Jiao, Hongxia Ren, Y. Li, J. Zhou, C. Duan, L. Lu
- Medicine, Biology
- Molecular and Cellular Biochemistry
Insulin-like growth factor (IGF)-I and IGF-II play major roles in the regulation of skeletal muscle growth and differentiation, and both are locally expressed in muscle cells. Recent studies have… Expand
Insulin-Like Growth Factor Signaling during Myogenesis.
- Hongxia Ren
IGF-II stimulates both mitogenesis and myogenesis through its binding and activation of the IGF-I receptor (IGF-1R). How this growth factor pathway promotes these two opposite cellular responses is… Expand
Gpr17 signaling decreases GLP-1 secretion in GLUTag cells
Background and Hypothesis: The incidence of obesity and diabetes continues to rise in devastatingly high proportions, making the need for safe, affordable, and effective treatment increasingly… Expand