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A highly practical, catalytic enantioselective cyclic phosphite addition to aldehydes and ketones was developed. The reaction rate of the asymmetric hydrophosphonylation was significantly enhanced by the addition of silver carbonate. Particularly, significant improvement has been achieved on the asymmetric hydrophosphonylation of unactivated ketones, giving… (More)
In the title mol-ecule, C(24)H(23)Cl(2)N(3)O(7), the central benzene ring forms dihedral angles of 65.71 (1) and 44.42 (1)° with the pyrimidine ring and the terminal benzene ring, respectively. In the crystal, molecules are linked via C-H⋯O hydrogen bonds.
In the title mol-ecule, C(12)H(15)Cl(2)O(4)P, the cyclic dioxaphosphinane ring adopts a chair conformation. In the crystal, inter-molecular O-H⋯O hydrogen bonds link the mol-ecules into chains propagating along the b axis.
In the title mol-ecule, C(21)H(13)F(6)N(3)O(2), the pyridine ring forms dihedral angles of 1.7 (1) and 5.2 (1)° with the two benzene rings. In the crystal structure, inter-molecular N-H⋯O hydrogen bonds and π⋯π inter-actions [centroid-centroid distance of 3.628 (3) Å between aromatic rings] link mol-ecules into stacks along the c axis. The two… (More)
In the crystal structure of the title mol-ecule, C(13)H(18)BrO(4)P, the phospho-nate ring adopts a chair conformation. Mol-ecules are linked by an O-H⋯O hydrogen bond [O⋯O = 2.780 (3) Å] to form chains parallel to the c axis. Two C-H⋯O inter-actions help to stabilize the crystal structure.
In the title compound, C(34)H(18)Cl(2)F(6)O(6), one terminal trifluoro-methyl and one entire 2-chloro-4-(trifluoro-meth-yl)phenyl group are disordered with refined occupancy ratios of 0.715 (11):0.285 (11) and 0.517 (5):0.429 (5), respectively. In the crystal, weak inter-molecular C-H⋯O hydrogen bonds link the mol-ecules into ribbons propagating along the… (More)
BACKGROUNDS In insects, cholesterol is one of the membrane components in cells and a precursor of ecdysteroid biosynthesis. Because insects lack two key enzymes, squalene synthase and lanosterol synthase, in the cholesterol biosynthesis pathway, they cannot autonomously synthesize cholesterol de novo from simple compounds and therefore have to obtain… (More)
In the title compound, C(15)H(15)Cl(2)O(7)P, the benzene and furan rings form a dihedral angle of 73.54 (1)°. In the crystal, weak inter-molecular C-H⋯O hydrogen bonds link the mol-ecules into layers parallel to (100).