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Regulation of SIRT1 in cellular functions: role of polyphenols.

• Sangwoon Chung, Hongwei Yao, Samuel W. Caito, Jae-woong Hwang, Gnanapragasam Arunachalam, Irfan Rahman
• Archives of biochemistry and biophysics
• 2010

Sirtuin 1 (SIRT1) is known to deacetylate histones and non-histone proteins including transcription factors thereby regulating metabolism, stress resistance, cellular survival, cellular… (More)

RelB is differentially regulated by IkappaB Kinase-alpha in B cells and mouse lung by cigarette smoke.

• S R Eric Yang, Hongwei Yao, +10 authors Irfan Rahman
• American journal of respiratory cell and…
• 2009

The activation of transcription factor NF-kappaB is controlled by two main pathways: the classical canonical (RelA/p65-p50)- and the alternative noncanonical (RelB/p52)-NF-kappaB pathways. RelB has… (More)

P21-PARP-1 Pathway Is Involved in Cigarette Smoke-Induced Lung DNA Damage and Cellular Senescence

• Hongwei Yao, Isaac K Sundar, Vera Gorbunova, Irfan Rahman
• PloS one
• 2013

Persistent DNA damage triggers cellular senescence, which may play an important role in the pathogenesis of cigarette smoke (CS)-induced lung diseases. Both p21(CDKN1A) (p21) and poly(ADP-ribose)… (More)

Nrf2 inhibits epithelial-mesenchymal transition by suppressing snail expression during pulmonary fibrosis

• Wencheng Zhou, Xiaoting Mo, +6 authors Jian Gao
• Scientific reports
• 2016

Epithelial-mesenchymal transition (EMT) is a phenotype conversion that plays a critical role in the development of pulmonary fibrosis (PF). It is known that snail could regulate the progression of… (More)

Fatty Acid Oxidation Protects Against Hyperoxia-Induced Endothelial Cell Apoptosis and Lung Injury in Neonatal Mice.

• Hongwei Yao, J Gong, Abigail L. Peterson, X. -C. M. Lu, Peng Zhang, Phyllis A. Dennery
• 2018

In neonates, hyperoxia or positive pressure ventilation causes continued lung injury characterized by simplified vascularization and alveolarization, which are the hallmarks of bronchopulmonary… (More)

Nrf2 attenuates inflammatory response in COPD/emphysema: Crosstalk with Wnt3a/β‐catenin and AMPK pathways

• Wenhui Cui, Zhihui Zhang, +7 authors Jian Gao
• Journal of cellular and molecular medicine
• 2018

Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation and abnormal inflammatory response. Wnt/β-catenin and AMP-activated protein kinase (AMPK) have been… (More)

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