Learn More
We describe a wideband version of the Fast Multipole Method for the Helmholtz equation in three dimensions. It unifies previously existing versions of the FMM for high and low frequencies into an algorithm which is accurate and efficient for any frequency, having a CPU time of O(N) if low-frequency computations dominate, or O(N log N) if high-frequency(More)
STUDY DESIGN A new recombinant adenoviral vector expressing Sox9, a chondrocyte-specific transcription factor, was tested in a chondroblastic cell line and primary human intervertebral disc cells in vitro. Direct infection of intervertebral disc cells then was assessed in a rabbit model. OBJECTIVES To deliver a potentially therapeutic viral vector(More)
Human cancers, including breast cancers, comprise clones differing in mutation content. Clones evolve dynamically in space and time following principles of Darwinian evolution, underpinning important emergent features such as drug resistance and metastasis. Human breast cancer xenoengraftment is used as a means of capturing and studying tumour biology, and(More)
A long-standing area of materials science research has been the study of electrostatic, magnetic, and elastic fields in composites with densely packed inclusions whose material properties differ markedly from that of the background. While powerful tools exist for dilute suspensions, accurate calculations in the close-to-touching case have been carried out(More)
PURPOSE This study was designed to investigate whether nuclear receptor agonists can be used as potential differentiation therapy agents for human osteosarcoma. EXPERIMENTAL DESIGN Four osteosarcoma cell lines (143B, MNNG/HOS, MG-63, and TE-85) were treated with proliferator-activated receptor (PPAR)gamma agonists, troglitazone and ciglitazone, and a(More)
Myxoid liposarcoma displays variably aggressive behavior and responds poorly to available systemic therapies. Expression profiling followed by tissue microarray validation linked to patient outcome is a powerful approach for validating biological mechanisms and identifying prognostic biomarkers. We applied these techniques to independent series of primary(More)
Clear cell sarcoma is an aggressive malignancy occurring most commonly in the distal extremities of young adults, characterized by t(12;22)(q13;q12) creating the chimeric fusion oncoprotein EWS-ATF1. We assessed growth inhibition and differentiation effects of histone deacetylase inhibitors MS-275 and romidepsin (depsipeptide, FK228) on clear cell sarcoma(More)