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A procedure is reported for the compression of rank-deficient matrices. A matrix A of rank k is represented in the form A = U • B • V , where B is a k × k submatrix of A, and U , V are well-conditioned matrices that each contain a k × k identity submatrix. This property enables such compression schemes to be used in certain situations where the singular(More)
We describe a wideband version of the Fast Multipole Method for the Helmholtz equation in three dimensions. It unifies previously existing versions of the FMM for high and low frequencies into an algorithm which is accurate and efficient for any frequency, having a CPU time of O(N) if low-frequency computations dominate, or O(N log N) if high-frequency(More)
Myxoid liposarcoma displays variably aggressive behavior and responds poorly to available systemic therapies. Expression profiling followed by tissue microarray validation linked to patient outcome is a powerful approach for validating biological mechanisms and identifying prognostic biomarkers. We applied these techniques to independent series of primary(More)
A long-standing area of materials science research has been the study of electrostatic, magnetic, and elastic fields in composites with densely packed inclusions whose material properties differ markedly from that of the background. While powerful tools exist for dilute suspensions, accurate calculations in the close-to-touching case have been carried out(More)
1 The disease is at present incurable once it has metastasized, and most deaths from this disease are due to metastases that are highly resistant to current conventional therapies. Prostate cancer is considered a multifocal disease that generally consists of a dominant cancer and one or more concurrent cancers of smaller volume with different histological(More)
Tenosynovial giant cell tumor is a neoplastic disease of joints that can cause severe morbidity. Recurrences are common following local therapy, and no effective medical therapy currently exists. Recent work has demonstrated that all cases overexpress macrophage colony-stimulating factor (CSF1), usually as a consequence of an activating gene translocation,(More)
INTRODUCTION Potassium channels encoded by human ether-à-go-go-related gene (hERG) underlie the cardiac rapid delayed rectifier K(+) channel current (I(Kr)). Acidosis occurs in a number of pathological situations and modulates a range of ionic currents including I(Kr) . The aim of this study was to characterize effects of extracellular acidosis on hERG(More)
Treatment resistance, the major challenge in the management of advanced prostate cancer, is in part based on resistance to apoptosis. The Inhibitor of Apoptosis (IAP) family is thought to play key roles in survival and drug resistance of cancer via inhibition of apoptosis. Of the IAP family members, cIAP1, cIAP2, XIAP and survivin are known to be(More)