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Migration and proliferation of smooth muscle cells are key to a number of physiological and pathological processes, including wound healing and the narrowing of the vessel wall. Previous work has shown links between inflammatory stimuli and vascular smooth muscle cell proliferation and migration through mitogen-activated protein kinase (MAPK) activation,(More)
Programmable routers supporting virtualization are a key building block for bridging the gap between new Internet protocols and their deployment in real operational networks. This article presents the design and implementation of PEARL, a ProgrammablE virtuAl Router pLatform with relatively high-performance. It offers high flexibility by allowing users to(More)
Inflammatory activation of monocytes is an essential part of both innate immune responses and the pathogenesis of conditions such as atherosclerosis. However, the mechanisms which modulate the response of monocytes to inflammatory stimuli are still poorly understood. Here, we report that tribbles-2 (trb-2) is a novel regulator of inflammatory activation of(More)
OpenFlow is one of the most potential technique to enable innovation in network. To enable OpenFlow more flexibility and high-efficiency, multi-table pipeline has been introduced in OpenFlow. A HAL(Hardware Abstraction Layer) is proposed to address the incompatibility of flow table pipeline between legacy switch hardware and the controller. However, the(More)
One of the key challenges of biology in the post-genomic era is to assign function to the many genes revealed by large-scale sequencing programmes, since only a small fraction of gene function can be directly inferred from the coding sequence. Identifying interactions between proteins is a substantial part in understanding their function. The main(More)
Inflammatory activation of monocytes is a hallmark event in cardiovascular disease. Activated monocytes migrate into atherosclerotic lesions, differentiate into macrophages and ingest lipids to become foam cells. These, in turn, through interaction with other inflammatory cell types contribute to plaque instability and are thought to play a key role in the(More)
Signalling pathways modulated by the family of IL-1/TLR receptors are central to innate immune responses. Novel components playing key regulatory roles in these pathways continue to be isolated. Here we describe the use of autocatalytic vectors for identifying critical components of these signalling pathways. The method was tested with a vector system where(More)
Mapping of intracellular signalling networks has attracted a lot of attention during recent years. Approaches which have been used to characterise functional and physical relationships within signalling systems and to identify novel components have included bioinformatics, genomics, proteomics and genetics. However, the importance of feedback loops in the(More)
Packet classification has been studied extensively in the past decade. While many efficient algorithms have been proposed, the lack of deterministic performance has hindered the adoption and deployment of these algorithms: the expensive and power-hungry TCAM is still the de facto standard solution for packet classification. In this work, in contrast to(More)
In recent years, there has been a growing interest in multi/many core processors as a target architecture for high performance software router. This is a clear difference from the previous trend to use dedicated network processors and hardware components. Because of its key position in routers, hardware IP lookup implementation has been intensively studied(More)