Hongsheng Wang

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A checkpoint that monitors cytokinesis in Schizosaccharomyces pombe.

Jianping Liu, Hongsheng Wang, Mohan K Balasubramanian
Journal of cell science
2000

Cell division in Schizosaccharomyces pombe is achieved through the use of a medially positioned actomyosin ring. A division septum is formed centripetally, concomitant with actomyosin ring… (More)

Drc1p/Cps1p, a 1,3-beta-glucan synthase subunit, is essential for division septum assembly in Schizosaccharomyces pombe.

Jianping Liu, Hongsheng Wang, Dannel McCollum, Mohan K Balasubramanian
Genetics
1999

Schizosaccharomyces pombe divides by medial fission through the use of an actomyosin-based contractile ring. A division septum is formed centripetally, concomitant with ring constriction. Although… (More)

A reporter mouse reveals lineage-specific and heterogeneous expression of IRF8 during lymphoid and myeloid cell differentiation.

Hongsheng Wang, Ming De Yan, +10 authors Herbert C. Morse
Journal of immunology
2014

The IFN regulatory factor family member 8 (IRF8) regulates differentiation of lymphoid and myeloid lineage cells by promoting or suppressing lineage-specific genes. How IRF8 promotes hematopoietic… (More)

The CXCR7 chemokine receptor promotes B-cell retention in the splenic marginal zone and serves as a sink for CXCL12.

Hongsheng Wang, Natalie Beaty, +4 authors Herbert C. Morse
Blood
2012

The splenic marginal zone (MZ) is comprised of specialized populations of B cells, dendritic cells, and macrophages that are uniquely arrayed outside the white pulp follicles to screen the blood for… (More)

Transcription factor IRF8 plays a critical role in the development of murine basophils and mast cells.

Haruka Sasaki, Daisuke Kurotaki, +11 authors Tomohiko Tamura
Blood
2015

Basophils and mast cells play critical roles in host defense against pathogens and allergic disorders. However, the molecular mechanism by which these cells are generated is not completely… (More)

IRF8 regulates myeloid and B lymphoid lineage diversification.

Hongsheng Wang, Herbert C. Morse
Immunologic research
2009

Interferon regulatory factor 8 (IRF8) is a member of the IRF family of transcription factors whose members play critical roles in interferon (IFN) signaling pathways governing the establishment of… (More)

IRF8 regulates B-cell lineage specification, commitment, and differentiation.

Hongsheng Wang, Chang Hoon Lee, +5 authors Herbert C. Morse
Blood
2008

PU.1, IKAROS, E2A, EBF, and PAX5 comprise a transcriptional network that orchestrates B-cell lineage specification, commitment, and differentiation. Here we identify interferon regulatory factor 8… (More)

Functional variants in the promoter region of Chitinase 3-like 1 (CHI3L1) and susceptibility to schizophrenia.

Xinzhi Zhao, Ruqi Tang, +19 authors Lin He
American journal of human genetics
2007

The chitinase 3-like 1 gene (CHI3L1) is abnormally expressed in the hippocampus of subjects with schizophrenia and may be involved in the cellular response to various environmental events that are… (More)

The transcription factor IRF8 activates integrin-mediated TGF-β signaling and promotes neuroinflammation.

Yuko Yoshida, Ryusuke Yoshimi, +12 authors Keiko Ozato
Immunity
2014

Recent epidemiological studies have identified interferon regulatory factor 8 (IRF8) as a susceptibility factor for multiple sclerosis (MS). However, how IRF8 influences the neuroinflammatory disease… (More)

Systematic screening for polymorphisms in the CYP3A4 gene in the Chinese population.

Jing Du, Qinghe Xing, +10 authors Lin He
Pharmacogenomics
2006

OBJECTIVES Cytochrome P450 3A4 (CYP3A4) is a major CYP enzyme in the liver and intestine. It is involved in the metabolism of over 50% of all drugs currently in use. The present study was designed to… (More)

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