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OBJECTIVES The objective of this study was to determine the effect of inhibiting malonyl-CoA decarboxylase (MCD) on cardiac remodeling following myocardial infarction (MI) in rats. We used an ultrasound (US)-mediated microbubble (MB) approach for targeted delivery of a microRNA (miRNA) interference plasmid to the myocardium to silence MCD expression. (More)
CONTEXT The promising efficacy of Toll-like receptor 9 (TLR9) agonists for use against pathogenic infections, allergies, malignant neoplasms and autoimmunity have been demonstrated well in clinical studies, but the safety of TLR9 agonists is controversial. OBJECTIVE In light of the safety concerns, we conducted a systematic review and meta-analysis of(More)
OBJECTIVE To optimize the conditions for the extraction of ecdysterone from Stemmacantha uniflora. METHODS Conditions for the extraction were studied by three different methods as guided by the content of ecdysterone and solid material that present in the extract. RESULTS Methanol was the best solvent, water the second, ethanol was greatly effected by(More)
OBJECTIVE To study the clinical and pathological characteristics of chordoma in the skull base. METHOD The clinical manifestation, radiological finding and pathological characteristics in 20 patients with skull base chordoma were reviewed. Among them, 7 were immunohistochemical stained for keratin, epithelial membrane antigen, vimentin, glial fibrillary(More)
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