Learn More
OBJECTIVE To determine the potential effects of pioglitazone on beta-cell function in metabolic syndrome patients with impaired glucose tolerance and probe into the possible mechanisms. RESEARCH DESIGN AND METHODS Twenty-two subjects were treated with pioglitazone 30 mg/day for 4 months. At baseline and after treatment, each subject underwent an IVGTT.(More)
BACKGROUND Insulin is an essential treatment for both type 1 and 2 diabetes. Among the available routes of insulin administration, oral delivery is the most appealing option. OBJECTIVE The purpose of this study was to evaluate the pharmacodynamic and pharmacokinetic profiles of orally administered enteric insulin and compare the time-action of these oral(More)
OBJECTIVE To investigate the immunogenicity of a domestic recombinant human growth hormone (rhGH) preparation and assess its influence on the growth-promoting effect. METHODS We developed a specific and sensitive radioimmuno-precipitation assay to determine the anti-hGH-antibody (GH-Ab) in serum of GH-deficient (GHD) children treated with rhGH(More)
OBJECTIVE To evaluate the clinical efficacy and tolerability of pioglitazone monotherapy or in combination with sulfonylurea therapy in the treatment of chinese patients with type 2 diabetes. METHODS This 12-week study involved 117 patients with type 2 diabetes whose blood glucose was uncontrolled on a stable regimen of diet or oral sulfonylureas for at(More)
Multiplex diabetic families may be caused by mutations in genes of hepatocyte nuclear factors (matur i ty-onset diabetes of the young [MODY]1, -3, and -5), glucokinase (MODY2), insulin promoter factor-1 (MODY4), NeuroD1 (MODY6), mitochondrion ND1 and tRNA, and some other unknown genetic mutations. Recent studies showed that mutations of MODY are not common(More)
This investigation was made in regard to the changes of plasma Leptin, Tumor Necrosis Factor-alpha (TNF-alpha) and Neuropeptide Y (NPY) levels and their association with insulin resistance and beta-cell secretion function in normal glucose tolerant first-degree relatives of familial type 2 diabetic pedigrees in Chengdu area. Levels of Leptin, TNF-alpha, NPY(More)
OBJECTIVE To compare the metabolic status and pancreatic β-cell function in first-degree relatives (FDRs) of type 2 diabetic patients with normal glucose tolerance (NGT). MATERIALS AND METHODS Three hundred twelve subjects, who were NGT-FDR of type 2 diabetic patients and 1348 subjects, who were NGT individuals with no family history of diabetes, were(More)
  • 1