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HDL-mimicking peptide-lipid nanoparticles with improved tumor targeting.
By adding targeting ligands to nanoparticles that mimic high-density lipoprotein (HDL), tumor-targeted sub-30-nm peptide-lipid nanocarriers are created with controllable size, cargo loading, and shielding properties.
Targeting dendritic cells in lymph node with an antigen peptide-based nanovaccine for cancer immunotherapy.
Co-Delivery of Bee Venom Melittin and a Photosensitizer with an Organic-Inorganic Hybrid Nanocarrier for Photodynamic Therapy and Immunotherapy.
The addition of an immune checkpoint blockade to Ce6/MLT@SAB phototreatment further augmented anti-tumor effects, generating increased numbers of CD4+ and CD8+ T cells in tumors with concomitant reduction of myeloid-derived suppressor cells.
Tetrameric far‐red fluorescent protein as a scaffold to assemble an octavalent peptide nanoprobe for enhanced tumor targeting and intracellular uptake in vivo
- Haiming Luo, Jie Yang, Zhihong Zhang
- Biology, ChemistryFASEB journal : official publication of the…
- 24 February 2011
Owing to easy preparation, precise structural and functional control, and multivalent effect, Octa‐FNP provides a powerful tool for tumor optical molecular imaging and evaluating the targeting ability of numerous peptides in vivo.
Downregulation of ABI2 expression by EBV-miR-BART13-3p induces epithelial-mesenchymal transition of nasopharyngeal carcinoma cells through upregulation of c-JUN/SLUG signaling
A novel mechanism by which ABI2 downregulation by EBV-miR-BART13-3p promotes EMT and metastasis of NPC via upregulating c-JUN/SLUG signaling pathway is suggested.
Role of nanoparticle-mediated immunogenic cell death in cancer immunotherapy
Scavenger Receptor B1 is a Potential Biomarker of Human Nasopharyngeal Carcinoma and Its Growth is Inhibited by HDL-mimetic Nanoparticles
The identification of SR-B1 as a potential biomarker and the use of HPPS as an effective anti-NPC agent may shed new light on the diagnosis and therapeutics of NPC.
Hybrid melittin cytolytic Peptide-driven ultrasmall lipid nanoparticles block melanoma growth in vivo.
The excellent properties of α-melittin-NP give it potential clinical applications in solid tumor therapeutics through intravenous administration, and a widened safe dosage range for melanoma-bearing mice via intravenous injection.
Efficient cytosolic delivery of siRNA using HDL-mimicking nanoparticles.
Therapeutic application of RNA interference requires delivery of siRNAs into the cytoplasm of targeted cells and tissues, where they are recognized and associated with RNA-induced silencing complex (RISC) to perform their function.
Mechanistic insights into LDL nanoparticle-mediated siRNA delivery.
Photochemical internalization demonstrated that endolysosome disruption strategies significantly enhance LDL-mediated gene silencing (78% at 100 nM) and improved silencing efficiency was limited by the receptor-mediated entrapment of the LDL-chol-siRNA nanoparticles in endolySosomes.