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HDL-mimicking peptide-lipid nanoparticles with improved tumor targeting.
TLDR
By adding targeting ligands to nanoparticles that mimic high-density lipoprotein (HDL), tumor-targeted sub-30-nm peptide-lipid nanocarriers are created with controllable size, cargo loading, and shielding properties.
Co-Delivery of Bee Venom Melittin and a Photosensitizer with an Organic-Inorganic Hybrid Nanocarrier for Photodynamic Therapy and Immunotherapy.
TLDR
The addition of an immune checkpoint blockade to Ce6/MLT@SAB phototreatment further augmented anti-tumor effects, generating increased numbers of CD4+ and CD8+ T cells in tumors with concomitant reduction of myeloid-derived suppressor cells.
Tetrameric far‐red fluorescent protein as a scaffold to assemble an octavalent peptide nanoprobe for enhanced tumor targeting and intracellular uptake in vivo
TLDR
Owing to easy preparation, precise structural and functional control, and multivalent effect, Octa‐FNP provides a powerful tool for tumor optical molecular imaging and evaluating the targeting ability of numerous peptides in vivo.
Downregulation of ABI2 expression by EBV-miR-BART13-3p induces epithelial-mesenchymal transition of nasopharyngeal carcinoma cells through upregulation of c-JUN/SLUG signaling
TLDR
A novel mechanism by which ABI2 downregulation by EBV-miR-BART13-3p promotes EMT and metastasis of NPC via upregulating c-JUN/SLUG signaling pathway is suggested.
Scavenger Receptor B1 is a Potential Biomarker of Human Nasopharyngeal Carcinoma and Its Growth is Inhibited by HDL-mimetic Nanoparticles
TLDR
The identification of SR-B1 as a potential biomarker and the use of HPPS as an effective anti-NPC agent may shed new light on the diagnosis and therapeutics of NPC.
Hybrid melittin cytolytic Peptide-driven ultrasmall lipid nanoparticles block melanoma growth in vivo.
TLDR
The excellent properties of α-melittin-NP give it potential clinical applications in solid tumor therapeutics through intravenous administration, and a widened safe dosage range for melanoma-bearing mice via intravenous injection.
Efficient cytosolic delivery of siRNA using HDL-mimicking nanoparticles.
TLDR
Therapeutic application of RNA interference requires delivery of siRNAs into the cytoplasm of targeted cells and tissues, where they are recognized and associated with RNA-induced silencing complex (RISC) to perform their function.
Mechanistic insights into LDL nanoparticle-mediated siRNA delivery.
TLDR
Photochemical internalization demonstrated that endolysosome disruption strategies significantly enhance LDL-mediated gene silencing (78% at 100 nM) and improved silencing efficiency was limited by the receptor-mediated entrapment of the LDL-chol-siRNA nanoparticles in endolySosomes.
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