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Humanized mice that express the human UDP-glucuronosyltransferase (UGT) 1 locus have been developed in a Ugt1-null background as a model to improve predictions of human UGT1A-dependent drug clearance. Enzyme kinetic parameters (K(m) and V(max)) and pharmacokinetic properties of three probe drugs were compared using wild-type and humanized UGT1 mice that(More)
Nonstandard abbreviations: AUC = area under the curve, PEG = polyethylene glycol; PBS = phosphate buffered saline; NMP = N-methylpyrrolidone; wt = C57BL/6 mouse; Tg(UGT1 A1*28)Ugt1-/-= humanized UGT1 mice that express the UGT1A1*28 allele, pb = phenobarbital. This article has not been copyedited and formatted. The final version may differ from this version.(More)
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