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The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas
A cancer-promoting histone protein Mutations in the chromatin protein histone H3 are found in a number of pediatric cancers. The lysine-36–to–methionine (K36M) “oncohistone” mutation is seen inExpand
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USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response.
Dynamic regulation of RNF168-mediated ubiquitylation of histone H2A Lys13,15 (H2AK13,15ub) at DNA double-strand breaks (DSBs) is crucial for preventing aberrant DNA repair and maintaining genomeExpand
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Genetic effects of XRCC4 and ligase IV genes on human glioma
Ligase IV and XRCC4 genes, important molecules in the nonhomologous end-joining pathway for repairing DNA double-strand breaks, may play crucial roles in carcinogenesis. To detect their effects onExpand
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tion of tryptophan metabolism for colorectal cancer therapy : a systematic review
Colorectal cancer (CRC) is one of the most malignant cancers resulting from abnormal metabolism alterations. As one of the essential amino acids, tryptophan has a variety of physiological functions,Expand