Honglian Guo

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Small interfering RNA (siRNA) has the potential to influence gene expression with a high degree of target gene specificity. However, the clinical application of siRNA therapeutics has proven to be less promising as evidenced by its poor intracellular uptake, instability in vivo, and nonspecific immune stimulations. Recently, we have demonstrated that(More)
We demonstrate a newly-developed magneto-fluorescent carbon nanotube (CNT) mediated siRNA (CNT-siRNA) delivery system, which significantly silences our target of interest, gastrin-releasing peptide receptor (GRP-R), in neuroblastoma. CNT-siGRP-R resulted in a 50% silencing efficiency and a sustained efficacy of 9 days for one-time siRNA treatment in vitro,(More)
The inhibitory effect of yeast Pichia membranaefaciens on black spot decay of postharvest broccoli, caused by Alternaria alternata (Fr.) Keissler, was investigated and possible mechanisms were explored in both in vitro and in vivo experiments. There was a positive correlation between the concentration of yeast cells and reduction of hyphal growth or spore(More)
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