Honglei Xie

Publications12
h-index4
Citations70
Highly Influential Citations0
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Design, synthesis, and structure-activity relationship studies of benzothiazole derivatives as antifungal agents.
A series of compounds with benzothiazole and amide-imidazole scaffolds were designed and synthesized to combat the increasing incidence of drug-resistant fungal infections. The antifungal activity of… Expand
  • 32
[Regulation of sonic hedgehog on vascular endothelial growth factor, basic fibroblast growth factor expression and secretion in bone marrow mesenchymal stem cells].
OBJECTIVE Sonic hedgehog (Shh) signaling pathway is involved in an important part of regulating angiogenesis. To investigate the effects of recombinant Shh N-terminate (rShh-N) on the expression and… Expand
  • 11
Design, synthesis and biological evaluation of N,N-3-phenyl-3-benzylaminopropanamide derivatives as novel cholesteryl ester transfer protein inhibitor.
A series of N,N-3-phenyl-3-benzylaminopropanamide derivatives were identified as novel CETP (cholesteryl ester transfer protein) inhibitors. In our previous study, lead compound L10 was discovered by… Expand
  • 5
The therapeutic potential of CETP inhibitors: a patent review
  • X. Wang, W. Li, +6 authors D. Zhao
  • Medicine
  • Expert opinion on therapeutic patents
  • 15 February 2018
ABSTRACT Introduction: Epidemiological studies have identified that high levels of low-density lipoprotein-cholesterol (LDL-C) and low levels of high-density lipoprotein-cholesterol (HDL-C) are two… Expand
  • 8
Discovery of novel N,N-3-phenyl-3-benzylaminopropionanilides as potent inhibitors of cholesteryl ester transfer protein in vivo.
Epidemiological studies have identified that the risk of cardiovascular events increases due to the decreased levels of high density lipoprotein-cholesterol and the elevated levels of low density… Expand
  • 4
Determining Neu5Ac in infant formula with ultra‐performance liquid chromatography–tandem mass spectrometry
The aim of this work was to measure N-acetylneuraminic acid (Neu5Ac) in milk-based infant formulas. The analysis was performed by ultra-performance liquid chromatography–tandem mass spectrometry… Expand
  • 3
Detection of protein adduction derived from dauricine by alkaline permethylation
AbstractDauricine is a bisbenzylisoquinoline alkaloid derivative and has shown multiple pharmacological properties. Despite this, our previous study demonstrated that dauricine induced severe lung… Expand
  • 3
Design, synthesis, antitumor activity and theoretical calculation of novel PI3Ka inhibitors.
PI3Kα has been identified as an ideal target to treat with PIK3CA gene mutation disease, including drugs such as Alpelisib and Copanlisib. Five purine analogues and four thiazole analogues were… Expand
  • 1
Design, synthesis and biological evaluation of novel cholesteryl ester transfer protein inhibitors bearing a cycloalkene scaffold.
Cholesteryl ester transfer protein (CETP) is a potential target for cardiovascular disease therapy as inhibition of CETP leads to increased HDL-C in humans. Based on the structure of Merck's biphenyl… Expand
  • 2
Synthesis of novel β-propanamides to inhibit cholesteryl ester transfer protein (CETP)
Abstract A novel series of β -propanamide derivatives as inhibitors of cholesteryl ester transfer protein (CETP) were synthesized. Previously, H3 (IC 50 2 μmol/L) was observed to inhibit CETP… Expand