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CRTh2 receptor is an important mediator of inflammatory effects and has attracted much attention as a therapeutic target for the treatment of conditions such as asthma, COPD, allergic rhinitis and… (More)
Abstract The previously unknown 1,1-dichloro-2,3,4,5-tetramethyl-1-silacylopenta-2,4-diene ( 3 ) was prepared in a three-step synthesis starting from zirconocene dichloride, 2-butyne, and… (More)
In the present work, molecular modeling studies have been reported on a series of diazine indole acetic acid derivatives to analyze the structure-activity relationship studies of CRTH2 using fragment… (More)
A silaspirotropylidene, 5, has been obtained from the reaction of the lithium salt of tetramethylsilole dianion (3) with 2 equiv of diphenylcyclopropenone, followed by quenching with Me3SiCl. The… (More)
Abstract A monopyrene-imine derivative 1 is a highly selective and sensitive “turn-on” fluorogenic probe for diethyl chlorophosphate (DCP), a stimulant for organophosphorus nerve agents. Upon… (More)
Abstract To improve the therapeutic efficacy of 20(s)-camptothecin (CPT) polymeric drugs containing CPT have been designed. A new CPT-conjugate, 3,6- endo… (More)