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Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds
Promoting Pluripotency A specialized mammalian cell can be set back to the pluripotent state either by transfer of the somatic cell nucleus into an oocyte or by delivery of exogenousExpand
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Directed differentiation of human embryonic stem cells into functional hepatic cells
The differentiation capacity of human embryonic stem cells (hESCs) holds great promise for therapeutic applications. We report a novel three‐stage method to efficiently direct the differentiation ofExpand
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Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells
Human pluripotent stem cells represent a potentially unlimited source of functional pancreatic endocrine lineage cells. Here we report a highly efficient approach to induce human embryonic stem (ES)Expand
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Genomic Characterization of Severe Acute Respiratory Syndrome-Related Coronavirus in European Bats and Classification of Coronaviruses Based on Partial RNA-Dependent RNA Polymerase Gene Sequences
ABSTRACT Bats may host emerging viruses, including coronaviruses (CoV). We conducted an evaluation of CoV in rhinolophid and vespertilionid bat species common in Europe. Rhinolophids carried severeExpand
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Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors.
(Cell Stem Cell 4, 16–19; January 9, 2009)In our recent article, we unfortunately misquoted the findings in a recent study by Ying et al. (2008)xThe ground state of embryonic stem cell self-renewal.Expand
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Induction of Pluripotency in Mouse Somatic Cells with Lineage Specifiers
The reprogramming factors that induce pluripotency have been identified primarily from embryonic stem cell (ESC)-enriched, pluripotency-associated factors. Here, we report that, during mouse somaticExpand
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MEK/ERK signaling contributes to the maintenance of human embryonic stem cell self-renewal.
MEK/ERK signaling plays a crucial role in a diverse set of cellular functions including cell proliferation, differentiation and survival, and recently has been reported to negatively regulate mouseExpand
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Social Influence Bias : A Randomized Experiment
vidually minor compounds is important. Future research is required to determine if this is also true for ecosystems that emit larger quantities of isoprene and/or monoterpenes. The minor species withExpand
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Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells
Human induced pluripotent stem (iPS) cells are similar to embryonic stem (ES) cells, and can proliferate intensively and differentiate into a variety of cell types. However, the hepaticExpand
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In vitro derivation of functional insulin-producing cells from human embryonic stem cells
The capacity for self-renewal and differentiation of human embryonic stem (ES) cells makes them a potential source for generation of pancreatic beta cells for treating type I diabetes mellitus. Here,Expand
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