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The genetic mechanisms mediating the adaptation of Mycobacterium tuberculosis within the host are poorly understood. The best-characterized regulatory systems in this organism include sigma factors and two-component signal transduction systems. mprAB is a two-component system required by M. tuberculosis for growth in vivo during the persistent stage of(More)
Establishment and maintenance of persistent, latent infection by Mycobacterium tuberculosis are dependent on expression of the mprA-mprB regulatory system. Previously, MprA and MprB were shown to participate in phosphotransfer reactions characteristic of two-component signaling systems. To begin identifying downstream effector genes regulated by mprA-mprB(More)
Mycobacterium tuberculosis remains a significant global health concern largely due to its ability to persist for extended periods within the granuloma of the host. While residing within the granuloma, the tubercle bacilli are likely to be exposed to stress that can result in formation of aberrant proteins with altered structures. Bacteria encode stress(More)
To protect hard disk data confidentiality and integrity, AEIVV associates one unique IV with each disk sector; then, it applies authenticated encryption of AES-CCM to the protected sector and constructs hash tree upon IV storage. Through assuring IV to be trusted or un-tampered, data can be protected firmly. To make it an available way for disk protection,(More)
Gout is a common arthritis resulting from increased serum urate, and many loci have been identified that are associated with serum urate and gout. However, their influence on the progression from elevated serum urate levels to gout is unclear. This study aims to explore systematically the effects of genetic variants on the pathogenesis in approximately(More)
Elevated serum urate, which is regulated at multiple levels including genetic variants, is a risk factor for gout and other metabolic diseases. This study aimed to investigate the association between UCP2 variants and serum urate as well as hyperuricemia in a Chinese population. In total, 4332 individuals were genotyped for two common UCP2 variants, -866G/A(More)
Data encryption is the most important way to provide security in hostile environment. Nearly all of the existing data encryption techniques require a lot of arithmetic and logical computations, which makes their deployment in embedded devices very difficult. To realize firm data encryption without much computation, a novel scheme of physically-embedded data(More)
Hardware/software partitioning is a crucial problem in hardware/software co-design. In this paper, we deeply investigate genetic algorithm (GA) for hardware/software partitioning, our co-design targets a heterogeneous multicore system on chip (SoC) which consists of several different types of processing engines(PE), Communicating structure adopts NOC, We(More)
Clock domain crossing (CDC) is an important issue in integrated circuit (IC) design and verification. In this paper, We present the design of 5 types of CDC schemes in our developed SOC chip with multi working mode and ten clock domain, deeply describe an approach using assertion-based verification (ABV) to verify proper functionality for CDC signals. Taped(More)