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TXNIP potentiates Redd1-induced mTOR suppression through stabilization of Redd1
It is collectively demonstrated that TXNIP stabilizes Redd1 protein induced by ATF4 in response to 2-DG, resulting in potentiation of mTOR suppression, the first study to identify TXNip as a novel member of the mTOR upstream that acts as a negative regulator in Response to stress signals.
Silencing of Twist1 sensitizes NSCLC cells to cisplatin via AMPK-activated mTOR inhibition
In conclusion, silencing of Twist1 sensitizes lung cancer cells to cisplatin via stimulating AMPK-induced mTOR inhibition, leading to a reduction in Mcl-1 protein.
Nidus vespae protein inhibiting proliferation of HepG2 hepatoma cells through extracellular signal-regulated kinase signaling pathways and inducing G1 cell cycle arrest.
It is demonstrated that NVP(1) inhibits proliferation of HepG2 through ERK signaling pathway and could be a potential drug for liver cancer, as indicated by nuclear chromatin condensation.