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A trial fibrillation (AF) is of public health importance and profoundly increases morbidity, mortality, and health-related expenditures. Morbidities include the increased risks of cardiovascular outcomes such as heart failure and stroke and the deleterious effects on quality of life (QOL), functional status, and cognition. The clinical epidemiology of AF,(More)
Blood pressure (BP) is a heritable determinant of risk for cardiovascular disease (CVD). To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP) and pulse pressure (PP), we genotyped ∼50 000 single-nucleotide polymorphisms (SNPs) that capture variation in ∼2100 candidate genes for cardiovascular(More)
Protein sequence contains clues to its function. Functional prediction from sequence presents a challenge particularly for proteins that have low or no sequence similarity to proteins of known function. Recently, machine learning methods have been explored for predicting functional class of proteins from sequence-derived properties independent of sequence(More)
Chronic low-grade inflammation reflects a subclinical immune response implicated in the pathogenesis of complex diseases. Identifying genetic loci where DNA methylation is associated with chronic low-grade inflammation may reveal novel pathways or therapeutic targets for inflammation. We performed a meta-analysis of epigenome-wide association studies (EWAS)(More)
Leveraging machine learning has been proven as a promising avenue for addressing many practical circuit design and verification challenges. We demonstrate a novel active learning guided machine learning approach for characterizing circuit performance. When employed under the context of support vector machines, the proposed probabilistically weighted active(More)
The emergence of digitally-intensive analog circuits introduces new challenges to formal verification due to increased digital design content, and non-ideal digital effects such as finite resolution, round-off error and overflow. We propose a machine learning approach to convert digital blocks to conservative analog approximations via the use of <i>kernel(More)
BACKGROUND Although growing evidence from trials and population-based studies has supported a protective role for flavonoids in relation to risk of certain chronic diseases, the underlying mechanisms remain unclear. Several previous studies focused on individual inflammatory biomarkers, but because of the limited specificity of any individual marker, an(More)
The suppression of tumorigenicity 2/IL-33 (ST2/IL-33) pathway has been implicated in several immune and inflammatory diseases. ST2 is produced as 2 isoforms. The membrane-bound isoform (ST2L) induces an immune response when bound to its ligand, IL-33. The other isoform is a soluble protein (sST2) that is thought to be a decoy receptor for IL-33 signaling.(More)
Drowsiness presents major safety concerns for tasks that require long periods of focus and alertness. While there is a body of work on drowsiness detection using EEG signals in neuroscience and engineering, there exist unanswered questions pertaining to the best mechanisms to use for detecting drowsiness. Targeting a range of practical safety-awareness(More)