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Four new iridoids, 2'-O-(E)-coumaroylshanzhiside (1), 6'-O-(E)-coumaroylshanzhiside (2), 8α-butylgardenoside B (3), 6α-methoxygenipin (4), and one new phenylpropanoid glucoside, 5-(3-hydroxypropyl)-2-methoxyphenyl β-d-glucopyranoside (5), together with sixteen known compounds, were isolated from the edible flowers of wild Gardenia jasminoides J.Ellis. Their(More)
Differentiation-specific microRNAs may play a critical role in MSC differentiation, and they can be altered by PDGF signaling. We propose that PDGF modulates MSC differentiation by regulating microRNA expression. Therefore, we investigated whether PDGF treatment could alter the expression profile of miRNAs in MSCs. Furthermore, we assessed the osteoblast(More)
ETHNOPHARMACOLOGICAL RELEVANCE Hawthorn (Crataegus pinnatifida Bunge) leave have been used to treat cardiovascular diseases in China and Europe. Hawthorn leave flavonoids (HLF) are the main part of extraction. Whether hawthorn leave flavonoids could attenuate the development of atherosclerosis and the possible mechanism remain unknown. MATERIALS AND(More)
Leptin and vascular cell adhesion molecules-1 (VCAM-1) are two important mediators in obesity-related osteoarthritis, while the molecular mechanism linking leptin to VCAM-1 production is still obscure. Here we show that leptin upregulates VCAM-1 mRNA and protein levels in a time- and dose-dependent manner. Mechanistically, leptin induces VCAM-1 promoter(More)
A new saponin, isonarthogenin 3-O-β-d-glucopyranosyl-(1→4)-β-d-galactopyranoside (1), together with twelve known compounds, were isolated from the rhizomes of Polygonatum sibiricum. The structures of these compounds were elucidated by analysis of their 1D/2D NMR and MS data. Among them, phenol compounds 4-7 and 9-10 showed significant inhibitions against(More)
To study the chemical constituents of Trichosanthes kirilowii Maxim., chromatographic methods such as D101 macroporous resin, silica gel column chromatographic technology, Sephadex LH-20, octadecylsilyl (ODS) column chromatographic technique and preparative HPLC were used and nine compounds were isolated from a 95% (v/v) ethanol extract of the plant. By(More)
The chemical constituent research on the ethyl acetate extracts of fermentation liquid of the marine fungus Trichoderma atroviride G20-12 led to the isolation of two new compounds, 2-hydroxybutan-3-yl 5'-(2''-hydroxy-N-(2'''-oxobutan-3'''-yl)propanamido)butanoate (1) and 3-hydroxy-5-(4-hydroxybenzyl)dihydrofuran-2(3H)-one (2). The structures of the new(More)
Five indole alkaloids and two phenylethylamine derivatives were isolated from the ethyl acetate extract of the fermentation broth of the marine bacterium Pantoea agglomerans P20-14. Their structures were identified as N-(4-hydroxyphenethyl)-2-(1H-indol-3-yl)acetamide (1), 3-(p-hydroxy)benzoyl indole (2), 1,2-di(1H-indol-3-yl)ethane (3),(More)
Similarity matching is one of the most important operations for data mining over time series. But previous works mainly focus on certain data. With the development of the internet of things and sensor networks, uncertain time series are emerging from various sources, which is a new challenge for data processing. In this paper, a novel similarity matching(More)
Two new compounds, 4-hydroxyphenethyl methyl succinate (1) and 4-hydroxyphenethyl 2-(4-hydroxyphenyl)acetate (2), were isolated from the EtOAc extract of the broth of the marine fungus Penicillium griseofulvum Y19-07. Five known compounds were also obtained in this study. The structures of the new compounds were elucidated by 1D and 2D NMR spectroscopy and(More)