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Characteristics of stem cells from human neuroblastoma cell lines and in tumors.
TLDR
It is postulate that a self-renewing multipotent tumor stem cell, which gives rise to diverse cell lineages, is the malignant progenitor of this cancer and I-type stem cells may be instrumental in the genesis and growth of tumors in the patient. Expand
MicroRNA miR-29 modulates expression of immunoinhibitory molecule B7-H3: potential implications for immune based therapy of human solid tumors.
TLDR
Differential modulation of this key immunoinhibitory molecule in tumor versus normal tissues may advance both cell-mediated immunotherapy and antibody-based targeted strategies using the B7-H3-specific mAb 8H9. Expand
Single-chain Fv-streptavidin substantially improved therapeutic index in multistep targeting directed at disialoganglioside GD2.
TLDR
Improvement in the T/NT ratio using pretargeting strategy may increase the efficacy and safety of scFv-based approaches in cancer therapy and a large repertoire of agents can potentially be explored. Expand
Antigen-dependent CD28 Signaling Selectively Enhances Survival and Proliferation in Genetically Modified Activated Human Primary T Lymphocytes
TLDR
It is demonstrated that the chimeric receptor 3G6-CD28 provides CD28 signaling upon specific recognition of the GD2 antigen on tumor cells, giving primary T cells given such an antigen-dependent survival advantage should be very useful to augment immune responses against tumor cells. Expand
Humanizing murine IgG3 anti-GD2 antibody m3F8 substantially improves antibody-dependent cell-mediated cytotoxicity while retaining targeting in vivo
TLDR
Humanization of m3F8 produced next generation anti-GD2 antibodies with substantially more potent ADCC in vitro and anti-tumor activity in vivo, which may be clinically more effective, while minimizing pain and HAMA side effects. Expand
Humanized Affinity-matured Monoclonal Antibody 8H9 Has Potent Antitumor Activity and Binds to FG Loop of Tumor Antigen B7-H3*
TLDR
The molecular epitope of 8H9 was determined to be dependent on the FG loop of B7-H3, a region critical to its function in immunologic blockade and unique among anti-B7- H3 antibodies published to date. Expand
Retargeting T Cells to GD2 Pentasaccharide on Human Tumors Using Bispecific Humanized Antibody
TLDR
The in vitro and in vivo antitumor properties of hu3F8-BsAb and its safety profile support its further clinical development as a cancer therapeutic, and provide the rationale for exploring aglycosylated IgG-scFv as a structural platform for retargeting human T cells. Expand
Interstitial Infusion of Glioma-Targeted Recombinant Immunotoxin 8H9scFv-PE38
TLDR
Interstitial infusion of 8H9scFv-PE38 shows potential for the treatment of hemispherical and brain stem glioma in rats harboring intracranial U87 xenografts and showed volumetric response to infusion by magnetic resonance imaging. Expand
A distinct gene expression signature characterizes human neuroblastoma cancer stem cells.
TLDR
Seven genes whose expression is consistently elevated exclusively in neuroblastoma cancer stem cells are identified and the identification and characterization of these genes could provide the basis for developing novel therapies for treatment of this lethal childhood cancer. Expand
A potent tetravalent T-cell-engaging bispecific antibody against CD33 in acute myeloid leukemia.
TLDR
It is concluded that the novel anti-CD33 IgG(L)-scFv BsAb construct reported here is a potential candidate for clinical development. Expand
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