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The generation of hyperglycemia-induced mitochondrial reactive oxygen species (ROS) is a key event in diabetic nephropathy development. The forkhead-box class O1 (FoxO1) and peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) proteins are implicated in oxidative stress. We investigated the in vivo association of FoxO1 and PGC-1α in renal(More)
Adiponectin is an adipocyte derived protein that plays pivotal roles in anti-oxidation, anti-inflammatory and insulin-sensitizing properties by activating two receptors, AdipoR1 and AdipoR2. Recent studies have shown that the down-regulation of AdipoR1 is a known cause of diabetic nephropathy (DN). Resveratrol (Resv), a natural polyphenol, has been(More)
We investigated blood nesfatin-1 levels in hypertension patients. We found that fasting plasma nesfatin-1 levels were significantly higher in hypertension patients than in control groups, especially in overweight/obese hypertension patients (4.5 ± 2.1 versus 3.3 ± 1.1 ng/ml, p < 0.01). Body mass index, systolic blood pressure and diastolic blood pressure(More)
BACKGROUND Brain Computer Interfaces (BCIs) are developed to translate brain waves into machine instructions for external devices control. Recently, hybrid BCI systems are proposed for the multi-degree control of a real wheelchair to improve the systematical efficiency of traditional BCIs. However, it is difficult for existing hybrid BCIs to implement the(More)
We present an imaging system for pan-neuronal recording in crawling Caenorhabditis elegans. A spinning disk confocal microscope, modified for automated tracking of the C. elegans head ganglia, simultaneously records the activity and position of ∼80 neurons that coexpress cytoplasmic calcium indicator GCaMP6s and nuclear localized red fluorescent protein at(More)
There have been many attempts to design brain-computer interfaces (BCIs) for wheelchair control based on steady state visual evoked potential (SSVEP), event-related desynchronization/synchronization (ERD/ERS) during motor imagery (MI) tasks, P300 evoked potential, and some hybrid signals. However, those BCI systems cannot implement the wheelchair navigation(More)
MicroRNAs play important roles in the pathogenesis of diabetic nephropathy (DN). In this study, we found that high glucose upregulated miR-27a expression in cultured glomerular mesangial cells and in the kidney glomeruli of streptozotocin (STZ)-induced diabetic rats. miR-27a knockdown prevented high glucose-induced mesangial cell proliferation and also(More)
BACKGROUND The incidence of thyroid cancer has progressively increased over the past few decades, and the most frequent types of this cancer are papillary thyroid carcinoma (PTC) and small primary tumors. In PTC, oncogene activation is known to occur at a high frequency. However, the potential roles of tumor suppressor genes in thyroid carcinogenesis remain(More)
Electroencephalogram- (EEG-) based brain-computer interface (BCI) systems usually utilize one type of changes in the dynamics of brain oscillations for control, such as event-related desynchronization/synchronization (ERD/ERS), steady state visual evoked potential (SSVEP), and P300 evoked potentials. There is a recent trend to detect more than one of these(More)