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Differential expression of microRNAs in plasma of patients with colorectal cancer: a potential marker for colorectal cancer screening
MiR-92 is significantly elevated in plasma of patients with CRC and can be a potential non-invasive molecular marker for CRC screening, and upregulated both in plasma and tissue samples. Expand
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms. Expand
Oncofetal H19-derived miR-675 regulates tumor suppressor RB in human colorectal cancer.
It is demonstrated that H19-derived miR-675, through downregulation of its target RB, regulates the CRC development and thus may serve as a potential target for CRC therapy. Expand
Methylation of protocadherin 10, a novel tumor suppressor, is associated with poor prognosis in patients with gastric cancer.
PCDH10 is a gastric tumor suppressor; its methylation at early stages of gastric carcinogenesis is an independent prognostic factor. Expand
Tumorigenic transformation by CPI-17 through inhibition of a merlin phosphatase
It is shown that CPI-17 levels are raised in several human tumour cell lines and that the downregulation of CPI- 17 induces merlin dephosphorylation, inhibits Ras activation and abolishes the transformed phenotype, showing that merlin is the decisive substrate of MYPT-1–PP1δ in tumour suppression. Expand
Epigenetic identification of ubiquitin carboxyl‐terminal hydrolase L1 as a functional tumor suppressor and biomarker for hepatocellular carcinoma and other digestive tumors
UCHL1 appears to be a functional tumor suppressor involved in the tumorigenesis of HCCs and other digestive cancers, including p53 and stabilizes p53 through the ubiquitination pathway. Expand
EGFR-TKI resistance in NSCLC patients: mechanisms and strategies.
The major mechanisms of acquired resistance to EGFR-TKIs are summarized, the development of rationally designed molecular target drugs in accordance with each mechanism is discussed, in the hope of shedding light on the great achievements obtained and tough obstacles the authors have to overcome in the battle against this deadly disease. Expand
EGFR Tyrosine Kinase Inhibitors Activate Autophagy as a Cytoprotective Response in Human Lung Cancer Cells
Autophagy inhibition represents a promising approach to improve the efficacy of EGFR-TKIs in the treatment of patients with advanced non-small-cell lung cancer. Expand
The Tumor Suppressor UCHL1 Forms a Complex with p53/MDM2/ARF to Promote p53 Signaling and Is Frequently Silenced in Nasopharyngeal Carcinoma
It is indicated that UCHL1 could deubiquitinate p53 and p14ARF and ubiquitinate MDM2 for p53 stabilization to promote p53 signaling, thus involved in nasopharyngeal carcinoma pathogenesis, whereas it is frequently silenced in this tumor. Expand
EZH2-mediated concordant repression of Wnt antagonists promotes β-catenin-dependent hepatocarcinogenesis.
The data indicate that EZH2-mediated epigenetic silencing contributes to constitutive activation of Wnt/β-catenin signaling and consequential proliferation of HCC cells, thus representing a novel therapeutic target for this highly malignant tumor. Expand