Hongbin Yuan

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NOD1 (nucleotide-binding oligomerization domain 1) protein is a member of the NLR (NACHT and leucine rich repeat domain containing proteins) protein family, which plays a key role in innate immunity as a sensor of specific microbial components derived from bacterial peptidoglycans and induction of inflammatory responses. Mutations in NOD proteins have been(More)
b S Supporting Information T he mammalian innate immune system serves as a first line of defense and relies on the detection of specific microbial ligands or " pathogen-associated molecular patterns " (PAMPs) by pattern recognition molecules (PRMs), acting as microbial sensors. 1À7 In this context, among the major classes of PRMs is the NLR (NACHT and(More)
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