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This paper deals with Kansei evaluation focusing on consumers’ psychological needs and personal taste. To do so, a preparatory study is conducted beforehand to obtain Kansei data of the products to be evaluated, in which products are assessed according to Kansei attributes by means of the semantic differential method and linguistic variables. These Kansei(More)
Nucleic acids bearing glycans of various structures have been under vigorous investigation in the past decade. The carbohydrate moieties of such complexes can serve as recognition sites for carbohydrate-binding proteins—lectins—and initiate receptor-mediated endocytosis. Therefore, carbohydrates can enhance cell targeting and internalization of nucleic(More)
This paper deals with multi-criteria decision making (MCDM) problems with multiple priorities, in which priority weights associated with the lower priority criteria are related to the satisfactions of the higher priority criteria. To do so, we first propose a prioritized weighted aggregation operator based on ordered weighted averaging (OWA) operator and(More)
This paper deals with the evaluation of Japanese traditional crafts, in which product items are assessed according to the so-called “Kansei” features by means of the semantic differential method. For traditional crafts, decisions on which items to buy or use are usually influenced by personal feelings/characteristics; therefore, we shall propose a(More)
3',5'-Cyclic diguanylic acid (c-di-GMP) is a naturally occurring small cyclic dinucleotide found in bacteria. There has been a recent surge of interest in the two-component signalling networks involving this molecule. This tutorial review introduces the biosynthesis of c-di-GMP, particularly the conserved domain features involved in its enzymatic synthesis(More)
3', 5'-Cyclic diguanylic acid (c-di-GMP) is a bacterial intracellular signaling molecule that plays a crucial role in the regulation of bacterial motility, adhesion, cell-to-cell communication, exopolysaccharide synthesis, biofilm formation and virulence. The recent finding that c-di-GMP can act as a danger signal on eukaryotic cells has prompted the study(More)
Mucosal infections and associated diseases remain a major socio-economic burden to society. Since parenteral immunizations fail to induce efficient protective immunity at mucosal surfaces, mucosal immunization is a logical approach to prevent and treat mucosally-initiated infections. All currently approved human mucosal vaccines are based on attenuated or(More)
Acinetobacter baumannii has emerged as a major cause of both community-associated and nosocomial infections worldwide. A. baumannii rapidly develops resistance to multiple antibiotics; as a result, infections by this pathogen have become increasingly difficult to treat. In this study, we evaluated the effect of 3',5'-cyclic diguanylic acid (c-di-GMP), a(More)
3',5'-Cyclic diguanylic acid (cdiGMP) is emerging as a universal bacterial second messenger in regulating bacterial growth on surfaces. It has been recently shown that cdiGMP stimulates innate immunity and enhances antigen-specific humoral and cellular immune responses. We herein report that intranasal (i.n.) administration with cdiGMP induces an acute but(More)