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Arsenic Trioxide Controls the Fate of the PML-RARα Oncoprotein by Directly Binding PML
TLDR
It is shown that arsenic binds directly to cysteine residues in zinc fingers located within the RBCC domain of PML-RARα and PML, identifying PML as a direct target of As2O3 and providing new insights into the drug’s mechanism of action and its specificity for APL. Expand
Reversal of multidrug resistance by co-delivery of paclitaxel and lonidamine using a TPGS and hyaluronic acid dual-functionalized liposome for cancer treatment.
TLDR
It is suggested that this dual-functional liposome for co-delivery of a cytotoxic drug and an MDR modulator provides a promising strategy for reversal of MDR in cancer treatment. Expand
Ca2+ regulates T-cell receptor activation by modulating the charge property of lipids
TLDR
This study provides a new regulatory mechanism of Ca2+ to T-cell activation involving direct lipid manipulation that has a positive feedback effect on amplifying and sustaining CD3 phosphorylation and should enhance T- cell sensitivity to foreign antigens. Expand
Design and synthesis of curcumin analogues for in vivo fluorescence imaging and inhibiting copper-induced cross-linking of amyloid beta species in Alzheimer's disease.
TLDR
Curcumin-based near-infrared fluorescence imaging probes for detecting both soluble and insoluble amyloid beta (Aβ) species and then an inhibitor that could attenuate cross-linking of Aβ induced by copper are designed and synthesized. Expand
Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer’s disease
TLDR
It is demonstrated that CRANAD-3, a curcumin analog, is capable of detecting both soluble and insoluble Aβ species and could monitor the decrease in Aβs after drug treatment, the first time that NIRF was used to monitor AD therapy. Expand
HAUSP deubiquitinated and stabilizes N-Myc in neuroblastoma
TLDR
This work has identified ubiquitin-specific protease 7 (USP7; also known as HAUSP) as a regulator of N-Myc function in neuroblastoma and suggests thatHAUSP inhibition is a potential therapy for MYCN-amplified tumors. Expand
Solution structure of calponin homology domain of Human MICAL-1
TLDR
The chiral homology domain of human MICAL-1 acts as a “spatially aggregating force” to CasL protein, which binds to it to form the “binding domain” of CasL. Expand
Solution structure of BRD7 bromodomain and its interaction with acetylated peptides from histone H3 and H4.
TLDR
It is found that BRD7 bromodomain contains the typical left-handed four-helix bundle topology, and can bind with weak affinity to lysine-acetylated peptides derived from hist one H3 with K9 or K14 acetylated and from histone H4 with K8, K12 or K16 acetylation. Expand
USP7: Target Validation and Drug Discovery for Cancer Therapy.
TLDR
USP7 is a promising therapeutic target and USP7 inhibitors hold promise as a new approach to cancer therapy. Expand
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
TLDR
Pentacyclic triterpenes represent a promising class of multiple-target antidiabetic agents that exert hypoglycemic effects, at least in part, through GP inhibition. Expand
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