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Risk assessment is an important and significant aid in the decision making process. Risk assessment is performed using 'model' and a model is a function of parameters which are usually affected by uncertainty. Some model parameters are affected by aleatory uncertainty and some others are affected by epistemic uncertainty. In this paper we propose a hybrid(More)
Calcitonin gene-related peptide (CGRP) is a 37 amino acid vasoactive neuropeptide that is widely distributed in central and peripheral nervous systems in mammals. CGRP was discovered in 1982 by molecular cloning of calcitonin (CT) gene. CGRP-specific mRNA appears to predominate in the hypothalamus while CT mRNA predominates in the thyroid. CGRP has an(More)
We have investigated the ability of a constitutively active Gq-alpha mutant, Q209L-alpha q, to regulate target gene expression. Transient expression in GH3 pituitary cells of a rat proximal prolactin promoter-chloramphenicol acetyltransferase construct (-187)PRL-CAT, was stimulated by co-expression of Q209L alpha q, but not by wild-type alpha q. Q209L-alpha(More)
Xenopus oocytes exhibit a receptor-evoked Cl- current that is mediated through the activation of phospholipase C (PLC) and release of intracellular Ca2+. The identity of PLC(s) mediating this effect is unknown. We have cloned cDNAs encoding a new form of PLC-beta from a Xenopus oocyte cDNA library. The Xenopus PLC-beta has substantial (33-64%) homology with(More)
  • L H Cao, L Wang, C Y Ji, L B Wang, H W Ma, Y Luo
  • 2012
Spondyloepiphyseal dysplasia (SED) is an autosomal dominant skeletal dysplasia characterized by short stature, abnormal epiphyses and flattened vertebral bodies. SED is mainly caused by mutations in the gene encoding the type II procollagen α-1 chain (COL2A1). We looked for mutations in COL2A1 in three unrelated Chinese families with SED. Putative mutations(More)
The Nature and Science is an international journal with a purpose to enhance our natural and scientific knowledge dissemination in the world under the free publication principle. Any valuable papers that describe natural phenomena and existence or any reports that convey scientific research and pursuit are welcome, including both natural and social(More)
Meckel syndrome (MKS) is a lethal, autosomal recessive condition characterised by an occipital meningoencephalocele, enlarged kidneys with multicystic dysplasia, fibrotic changes of the liver in the portal area with ductal proliferation, and postaxial polydactyly. Recently, a MKS gene has been mapped to chromosome 17q21-q24 in Finnish families, with no(More)
HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-CoA reductase, HMGCR) is the rate controlling enzyme (EC 1.1.1.88) of the mevalonate pathway, the metabolic pathway that produces cholesterol and other isoprenoids. This enzyme is the target of the widely available cholesterol lowering drugs (statins). HMGCR is anchored in the membrane of the endoplasmic(More)
Paternity testing can be done by older methods including ABO blood group typing, analysis of various other proteins and enzymes, or using human leukocyte antigen (HLA). However, DNA testing became the only formal and exact method for the paternity testing now. For DNA testing of paternity determination, the DNA collection using an easily obtained cheek swab(More)