HongGuang Ji

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Inflammatory cells such as phagocytes, neutrophils, and macrophages have been implicated in the pathogenesis of several forms of clinical and experimental tumor development. It is hypothesized that this process is mediated by the production of reactive species including NO., O2.-, H2O2, and ONOO- which inflict DNA damage. In this study, the role of NO. in(More)
Head and neck squamous cell carcinoma (HNSCC) development is closely associated with inflammation. Cyclooxygenase-2 (COX-2) is an important mediator of inflammation. Therefore, celecoxib, a selective inhibitor of COX-2, was hailed as a promising chemopreventive agent for HNSCC. Dose-dependent cardiac toxicity limits long-term use of celecoxib, but it seems(More)
The purpose of this study was to examine the effect of carbohydrate (CHO) augmentation on endurance performance and substrate utilization in aerobically trained women. Eight endurance-trained women completed a 24.2-km (15 mile) self-paced treadmill performance run under three conditions: CHO supplementation (S), CHO loading and supplementation (L+S), and(More)
Overexpression of cyclooxygenase-2 (COX-2) in oral mucosa has been associated with increased risk of head and neck squamous cell carcinoma (HNSCC). Celecoxib is a nonsteroidal anti-inflammatory drug, which inhibits COX-2 but not COX-1. This selective COX-2 inhibitor holds promise as a cancer preventive agent. Concerns about cardiotoxicity of celecoxib,(More)
The heterocyclic aromatic amines produced by high temperature cooking of foods containing creatin(in)e and amino acids (such as beef, pork, poultry and fish) are a class of potent animal carcinogens and have been implicated indirectly in human colon and pancreas carcinogenesis. We studied the urinary excretion of a mutagenic heterocyclic aromatic amine(More)
The metabolism of the heterocyclic amines has been extensively studied in rodents and limited studies have been conducted in nonhuman primates. A study has been undertaken on the metabolism of 2-amino-3,8-dimethylimadazo[4,5-f]quinoxaline (MeIQx) in human subjects consuming normal cooked foods. A variety of fish and meat products has been cooked in several(More)
A two-phase DLSM model is proposed to model transverse isotropic materials, in which the layer structure of the anisotropic materials is explicitly represented. Equations are derived to obtain elastic parameters of the two phase model from the elastic modules in parallel to the bedding planes and that in normal direction of the bedding planes. Then, the(More)
Shaft lining concrete itself has a certain degree of initial damage before being corroded by sulfate. In order to study the resistance of the concrete of the initial damage in different corrosion solution concentration of sulfate, samples of concrete without initial damage, loaded 50% ultimate load and loaded 70% ultimate load with initial damage concrete(More)
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