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The draft genome of sweet orange (Citrus sinensis)
Focused analysis on genes involved in vitamin C metabolism showed that GalUR, encoding the rate-limiting enzyme of the galacturonate pathway, is significantly upregulated in orange fruit, and the recent expansion of this gene family may provide a genomic basis.
Multiple Rice MicroRNAs Are Involved in Immunity against the Blast Fungus Magnaporthe oryzae1[C][W][OPEN]
Data indicate that miRNAs are involved in rice immunity against M. oryzae and that overexpression of miR160a or miR398b can enhance rice resistance to the disease.
Estimation of scavenging activity of phenolic compounds using the ABTS(*+) assay.
- N. Nenadis, Lan-fen Wang, M. Tsimidou, Hong-yu Zhang
- Chemistry, MedicineJournal of agricultural and food chemistry
- 26 June 2004
It can be argued that the ABTS(*+) assay may give an indication for the presence of antioxidants in a certain system but SARs cannot be readily inferred.
A universal molecular clock of protein folds and its power in tracing the early history of aerobic metabolism and planet oxygenation.
The existence and implications of a molecular clock of folds are described, a universal recurrence in the discovery of new structures in the world of proteins, using a phylogenomic structural census in hundreds of proteomes to build phylogenies and time lines of domains at fold and fold superfamily levels of structural complexity.
Rational drug repositioning by medical genetics
The 135 matches notably included the most illustrative examples of identical matches derived from GWAS, such as that 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) can lower blood cholesterol levels (hypercholesterolemia) and strongly suggest that the rationality principle can be applied to find new uses for old drugs and predict drug side effects based on mismatch information.
Natural products and drug discovery
Many antibiotics are used commercially, or are potentially useful in medicine for purposes other than their antimicrobial action, and are used as antitumor agents, enzyme inhibitors including powerful hypocholesterolemic agents, immunosuppressive agents, antimigraine agents, and so on.
Evaluation of a new copper(II)-curcumin complex as superoxide dismutase mimic and its free radical reactions.
Where is the hope for drug discovery? Let history tell the future.
The antialgal activity of 40 medicinal plants against Microcystis aeruginosa
- Yang-lei Yi, Y. Lei, Yue Yin, Hong-yu Zhang, Gaoxue Wang
- BiologyJournal of Applied Phycology
- 1 August 2012
In search of a botanical algicide, 40 traditional medicinal plants were screened for antialgal activity against the bloom-forming cyanobacterium Microcystis aeruginosa using coexistence culture system assay and the ethyl acetate extract of S. miltiorrhiza was observed to be more efficient than the other plant extracts.
Theoretical elucidation on the antioxidant mechanism of curcumin: a DFT study.
It was found that the antioxidant mechanism of curcumin was a H-atom abstraction from the phenolic group, not from the central CH2 group in the heptadienone link.