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Hydrogels with tunable stress relaxation regulate stem cell fate and activity
Natural extracellular matrices (ECMs) are viscoelastic and exhibit stress relaxation. However, hydrogels used as synthetic ECMs for three-dimensional (3D) culture are typically elastic. Here, weExpand
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YAP-independent mechanotransduction drives breast cancer progression
Increased tissue stiffness is a driver of breast cancer progression. The transcriptional regulator YAP is considered a universal mechanotransducer, based largely on 2D culture studies. However, theExpand
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Volume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments
For mesenchymal stem cells (MSCs) cultured in three dimensional matrices, matrix remodeling is associated with enhanced osteogenic differentiation. However, the mechanism linking matrix remodeling inExpand
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Structural Health Monitoring of Nuclear Containment Building Using Fiber Bragg Grating Sensor
Abstract Nuclear containment building is used as second blockage to protect us from a radiation leakage caused by the natural disaster or anyaccidents, so it's safety is important and must be keptExpand
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Prediction of Prestress Force on Grouted Tendon by Experimental Modal Analysis
The grouted tendon has been adopted to the containment building of some operating nuclear power plants in Korea and assessment of the prestress force on thegrouted tendon is being issued as an important pending problem for the continuous operation beyond their design life. Expand
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A Study on the Reduction Effect for Seismic Isolation System of Nuclear Power Plant
Seismic isolation systems which performance was verified from many experimental studies has been used general industry structures such as bridges, LNG tank and architecture structures to protect theExpand
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Mechanical confinement regulates cartilage matrix formation by chondrocytes
Cartilage tissue equivalents formed from hydrogels containing chondrocytes could provide a solution for replacing damaged cartilage. Previous approaches have often utilized elastic hydrogels.Expand
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Cell cycle progression in confining microenvironments is regulated by a growth-responsive TRPV4-PI3K/Akt-p27Kip1 signaling axis
A growth-responsive TRPV4-PI3K-p27 pathway regulates cell cycle progression for cancer cells in confining 3D microenvironments. In tissues, cells reside in confining microenvironments, which mayExpand
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Wet microcontact printing (µCP) for micro-reservoir drug delivery systems.
When micro-reservoir-type drug delivery systems are fabricated, loading solid drugs in drug reservoirs at microscale is often a non-trivial task. This paper presents a simple and effective solutionExpand
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Microchannel system for rate-controlled, sequential, and pH-responsive drug delivery.
Controlled delivery of drug at a constant rate, in a sequential order, or responsive to environment conditions has been pursued for a long time to enhance the efficacy of therapeutic molecules and toExpand
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