Hong-mei Xiao

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The human zona pellucida is composed of four glycoproteins (ZP1, ZP2, ZP3, and ZP4) and has an important role in reproduction. Here we describe a form of infertility with an autosomal recessive mode of inheritance, characterized by abnormal eggs that lack a zona pellucida. We identified a homozygous frameshift mutation in ZP1 in six family members. In vitro(More)
OBJECTIVE To screen mutations of tuberous sclerosis complex (TSC) patients to confirm a clinical diagnosis of TSC, and to perform prenatal diagnosis for families with mutations. METHODS In this study, PCR-denaturing high-performance liquid chromatography(DHPLC), supplemented with sequencing when necessary, was used to screen TSC1 and TSC2 mutations in 21(More)
OBJECTIVE To investigate the occurrence of ectopic pregnancy among women who received in vitro fertilization and assess the influential factors. METHODS The indications, methods of assisted conception and ectopic types were analyzed retrospectively after the patients received in vitro fertilization and embryo transfer (IVF-ET), intracytoplasmic sperm(More)
OBJECTIVE To evaluate the feasibility of using fluorescence in situ hybridization(FISH) for the detection of a few common chromosome aneuploidies on interphase nuclei of uncultured amniotic fluid cells. METHODS Amniotic fluid samples were taken from 55 women at 16-32 weeks of pregnancy; interphase FISH was performed for diagnosing Down syndrome and(More)
OBJECTIVE To observe the influence of patient's age, and the number of transferred-good-quality-embryos on multiple gestation rates in in vitro fertilization and embryo transfer (IVF-ET) cycles. METHODS In this retrospective study, a total of 4,395 patients who transferred fresh embryo between Jan 2004 and Nov 2006 was analyzed. According to the age, the(More)
AIM To study the effect of melatonin on the induction of LTP in CA3 area of hippocampus and to investigated its possible mechanisms. METHODS Melatonin and other drugs (Tacrine or DNQX) were microinjected into the CA3 area. By using extracellular electrophysiological recordings to observe the changes of the slope of fEPSP in the CA3 area. RESULTS (1)(More)
OBJECTIVE To observe the effects of musk and carterii birdw on the pathology and the expressions of inflammatory cytokines in chronic non-bacterial prostatitis (CNBP) rats treated with polygonum extract. METHODS Five male Wistar rats were used for the preparation of SC purified prostate protein solution, and another 48 randomly divided into four groups:(More)
OBJECTIVE To analyze the mutations in Cx30 gene in a Chinese family with hidrotic ectodermal dysplasia (HED) and to make prenatal diagnosis on the embryo which has been pregnant for 5 months. METHODS A family including 2 affected and 4 unaffected individuals was collected, and their informed consents were obtained. The affected woman had a five-month(More)
OBJECTIVE To investigate the clinical value of ultrasonography via vaginal in diagnosing uterine anomalies. METHODS Patients in Infertility Clinic were scanned by endovaginal sonography. Hysterosalpingography (HSG) or hysteroscopy were performed in patients with uterine anomalies confirmed by ultrasonography. RESULTS Twenty patients had uterine(More)
Objective The potential of all central nervous system synapses to exhibit long term potentiation (LTP) or long term depression (LTD) is subject to modulation by prior synaptic activity, a higher-order form of plasticity that has been termed metaplasticity. This study is designed to examine the plasticity and metaplasticity in the lateral perforant path of(More)