Hong-juan Zhang

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A series of amide-coupled benzoic nitrogen mustard derivatives as potential EGFR and HER-2 kinase inhibitors were synthesized and reported for the first time. Some of them exhibited significant EGFR and HER-2 inhibitory activity. Of all the studied compounds, compounds 5b and 5t exhibited the most potent inhibitory activity, which was comparable to the(More)
Nemo-like kinase (NLK) is an evolutionarily conserved serine/threonine protein kinase and belongs to the extracellular signal-regulated kinases/microtubule-associated protein kinase families (Erks/MAPKs). Previous studies have indicated that abnormal expressions of NLK played critical roles in various types of human cancers. Recent studies suggested that(More)
In flammable or explosive environments, an ultrasonic sensor for distance measurement poses an important engineering safety challenge, because the driving circuit uses an intermediate frequency transformer as an impedance transformation element, in which the produced heat or spark is available for ignition. In this paper, an intrinsically safe ultrasonic(More)
Transmitting data from sender to authorized receiver through a public media (insecure media) with full security is a challenging task. From the ancient time, different methods and techniques have been adopted to gain secure transmission of information. With the development of new technologies, the techniques used for securing information have also changed.(More)
To improve the convergence time of basic ant colony optimization algorithm and avoid falling in local best, a novel ant colony-genetic hybrid algorithm is proposed. Firstly, the self-adaptive strategy of evaporation coefficient is adopted to enhance global search ability. Secondly, the global pheromone update rule is introduced to restrict ants release(More)
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