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The active metabolite of the novel immunosuppressive agent leflunomide has been shown to inhibit the enzyme dihydroorotate dehydrogenase (DHODH). This enzyme catalyzes the fourth step in de novo pyrimidine biosynthesis. Self-organizing molecular field analysis (SOMFA), a simple three-dimensional quantitative structure-activity relationship (3D-QSAR) method(More)
Real-time intelligent analysis of HD videos has become one of the major areas of the current video analysis technology. This paper discusses large-scale video intelligent analysis using the Spark platform. In large-scale real-time video surveillance, a major problem is how to import the large-scale video streams into the analysis platform. In Spark, the(More)
OBJECTIVE To evaluate the effects of paroxetine on protein kinase PKA, PKC and CaMKII activities in different brain regions in a rat model of depression. METHODS Thirty-six adult male SD rats were randomized into 6 groups, including one control group (I) and 5 groups of depression model established by forcing the rats to swim for 4 weeks. The 5 depression(More)
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