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Trigochinins A-C: three new daphnane-type diterpenes from Trigonostemon chinensis.
- Hua-dong Chen, Sheng-ping Yang, +5 authors J. Yue
- Chemistry, MedicineOrganic letters
- 11 February 2010
This study suggested the revision of the C-6 stereochemistry of trigonothyrins A-C reported quite recently, which showed significant inhibition against MET tyrosine kinase activity.
Ophiobolin sesterterpenoids and pyrrolidine alkaloids from the sponge-derived fungus aspergillus ustus
Chemical examination of the fungus Aspergillus ustus isolated from the Mediterranean sponge Suberites domuncula yielded the five new ophiobolin-type sesterterpenoids 1–5 and the two new pyrrolidine…
Tulongicin, an Antibacterial Tri-Indole Alkaloid from a Deep-Water Topsentia sp. Sponge.
- Hong-bing Liu, G. Lauro, +5 authors C. Bewley
- Biology, MedicineJournal of natural products
- 24 August 2017
Tulongicin A is the first natural product to contain a di(6-Br-1H-indol-3-yl)methyl group linked to an imidazole core, and the coexistence of tri-indole 1 and bis-indoles alcohol 2 suggests a possible route to 1.
Organic carbonates from natural sources.
Phainanoids A-F, a new class of potent immunosuppressive triterpenoids with an unprecedented carbon skeleton from Phyllanthus hainanensis.
- Yao-yue Fan, Hua Zhang, +5 authors J. Yue
- Chemistry, MedicineJournal of the American Chemical Society
- 14 January 2015
Phainanoids A-F (1-6), six highly modified triterpenoids with a new carbon skeleton by incorporating two unique motifs of a 4,5- and a 5,4-spirocyclic systems, were isolated from Phyllanthus hainanensis and exhibited exceptionally potent immunosuppressive activities in vitro against the proliferation of T and B lymphocytes.
Trigochinins D-I: six new daphnane-type diterpenoids from Trigonostemon chinensis
Six new highly oxygenated daphnane-type diterpenoids, trigochinins De I( 1e6), were isolated from the twigs and leaves of Trigonostemon chinensis. Their structures with the absolute configuration…
Dammarane-type triterpenoids as 11β-HSD1 inhibitors from Homonoia riparia.
- J. Yu, Yu Shen, Hong-bing Liu, Y. Leng, Hua Zhang, J. Yue
- Chemistry, MedicineOrganic & biomolecular chemistry
- 11 June 2014
An exploration for 11β-HSD1 inhibitors from Homonoia riparia returned eight new dammarane-type triterpenoids, horipenoids A–H (1–8), and a known oleanane-type triterpenoid (9). Their structures were…
Chukrasones A and B: potential Kv1.2 potassium channel blockers with new skeletons from Chukrasia tabularis.
- Hong-bing Liu, Hua Zhang, P. Li, Zhao-bing Gao, J. Yue
- Chemistry, MedicineOrganic letters
- 10 August 2012
Two new limonoids, chukrasone A and B possessing the first 16,19-dinor limonoid backbone with an extended C3 unit at C-15, were isolated from Chukrasia tabularis and exhibited potential inhibition of the delayed rectifier K(+) current.
Sesquiterpenes from Dysoxylum oliganthum and Dysoxylum excelsum
- Hong-bing Liu, Chuan-Rui Zhang, +4 authors J. Yue
- Chemistry, MedicineJournal of Asian natural products research
- 14 February 2012
Three new sesquiterpenes, including C-10 in compounds 1–3 of a rare class was determined by using Snatzke's method and their structures were established on the basis of extensive spectroscopic analysis and chemical shifts.
Rational Design of a Novel Fluorescent Biosensor for β-Lactam Antibiotics from a Class A β-Lactamase
A rational design strategy was used to construct a sensitive “turn-on” biosensor for β-lactam antibiotics and β-lactamase inhibitors from a class A β-lactamase mutant with suppressed hydrolytic…