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Sema3A, a prototypical semaphorin, acts as a chemorepellent or a chemoattractant for axons by activating a receptor complex comprising neuropilin-1 as the ligand-binding subunit and plexin-A1 as the signal-transducing subunit. How the signals downstream of plexin-A1 are triggered upon Sema3A stimulation, however, is unknown. Here we show that, in the(More)
In this paper, we examine the problem of controlling multiple behaviour-based autonomous robots. Based on observations made from the study of social insects, we propose ve simple mechanisms used to invoke group behaviour in simple sensor-based mobile robots. The proposed mechanisms allow populations of behaviour-based robots to perform tasks without(More)
Cyclophilin D (CypD, encoded by Ppif) is an integral part of the mitochondrial permeability transition pore, whose opening leads to cell death. Here we show that interaction of CypD with mitochondrial amyloid-beta protein (Abeta) potentiates mitochondrial, neuronal and synaptic stress. The CypD-deficient cortical mitochondria are resistant to Abeta- and(More)
—The paradigm of cloud computing has spontaneously prompted a wide interest in market-based resource allocation mechanisms by which a cloud provider aims at efficiently allocating cloud resources among potential users. Among these mechanisms, auction-style pricing policies, as they can effectively reflect the underlying trends in demand and supply for the(More)
Multiple types of indirect evidence have been used to support theories of altered cortical connectivity in autism spectrum disorders (ASD). In other developmental disorders reduced spine expression is commonly found, while conditions such as fragile X syndrome show increased spine densities. Despite its relevance to theories of altered cortical(More)
Aging is an intricate phenomenon characterized by progressive decline in physiological functions and increase in mortality that is often accompanied by many pathological diseases. Although aging is almost universally conserved among all organisms, the underlying molecular mechanisms of aging remain largely elusive. Many theories of aging have been proposed,(More)
Epigenetic mechanisms such as post-translational histone modifications are increasingly recognized for their contribution to gene activation and silencing in the brain. Histone acetylation in particular has been shown to be important both in hippocampal long-term potentiation (LTP) and memory formation in mice. The involvement of the epigenetic modulation(More)
Inter-datacenter wide area networks (inter-DC WAN) carry a significant amount of data transfers that require to be completed within certain time periods, or deadlines. However, very little work has been done to guarantee such deadlines. The crux is that the current inter-DC WAN lacks an interface for users to specify their transfer deadlines and a mechanism(More)