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The neuronal ubiquitin/proteasomal pathway has been implicated in the pathogenesis of Alzheimer's disease (AD). We now show that a component of the pathway, ubiquitin C-terminal hydrolase L1 (Uch-L1), is required for normal synaptic and cognitive function. Transduction of Uch-L1 protein fused to the transduction domain of HIV-transactivator protein (TAT)(More)
Epigenetic mechanisms such as post-translational histone modifications are increasingly recognized for their contribution to gene activation and silencing in the brain. Histone acetylation in particular has been shown to be important both in hippocampal long-term potentiation (LTP) and memory formation in mice. The involvement of the epigenetic modulation(More)
In this paper, we examine the problem of controlling multiple behaviour-based autonomous robots. Based on observations made from the study of social insects, we propose ve simple mechanisms used to invoke group behaviour in simple sensor-based mobile robots. The proposed mechanisms allow populations of behaviour-based robots to perform tasks without(More)
DNA-dependent protein kinase (DNA-PK), which is involved in DNA double-stranded break repair and V(D)J recombination, comprises a DNA-targeting component called Ku and an approximately 460 kDa catalytic subunit, DNA-PKcs. Here, we describe the cloning of the DNA-PKcs cDNA and show that DNA-PKcs falls into the phosphatidylinositol (PI) 3-kinase family.(More)
Enterprise integration through integrated business information systems (IBIS) is necessary to achieve agility in the current age of hyper-competition. Multi-agent systems (MAS) provide a new paradigm for IBIS development. In this paper, we review the IBIS modeling and MAS literatures and find that the MAS paradigm provides an excellent approach for modeling(More)
—The paradigm of cloud computing has spontaneously prompted a wide interest in market-based resource allocation mechanisms by which a cloud provider aims at efficiently allocating cloud resources among potential users. Among these mechanisms, auction-style pricing policies, as they can effectively reflect the underlying trends in demand and supply for the(More)
Tone is an essential language phenomenon for Mandarin Chinese language. Until now, we still do not know exactly how context affects tone pattern variation in continuous Mandarin speech. In this paper, we proposed a decision tree based approach to obtain the quantitative result of tone pattern variation in continuous Mandarin speech. Many possible factors(More)
The Doppler spread, or equivalently, the mobile speed, is a measure of the spectral dispersion of mobile fading channel. Accurate estimation of the mobile speed is of importance in wireless mobile applications which require the knowledge of the rate of channel variations. This paper exploits the inherent cyclostationarity of linearly modulated signals,(More)