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Mutant V600E BRAF Increases Hypoxia Inducible Factor-1α Expression in Melanoma
TLDR
The data show for the first time that BRAF(V600E) mutation increases Hif-1alpha expression and melanoma cell survival under hypoxic conditions and suggest that effects of the oncogenic V600E BRAF mutation may be partially mediated through the HIF-1 alpha pathway. Expand
Mutant V600E BRAF increases hypoxia inducible factor-1alpha expression in melanoma.
TLDR
The data show for the first time that BRAF(V600E) mutation increases Hif-1alpha expression and melanoma cell survival under hypoxic conditions and suggest that effects of the oncogenic V600E BRAF mutation may be partially mediated through the HIF-1 alpha pathway. Expand
Hypophosphorylation of residue Y1045 leads to defective downregulation of EGFRvIII
TLDR
Comparisons with wild-type EGFR and EGFRvIII internalization, as well as gefitinib sensitive and resistant EGFR kinase mutations found in non-small cell lung carcinoma, suggest that hypophosphorylation of tyrosine residue 1045 is likely to be the cause for EG FRvIII escape from c-Cbl-induced ubiquitination and degradation, enhancing EGfrvIII’s ability to increase proliferation in breast cancer cells. Expand
Integration of metabolomic and transcriptomic data reveals metabolic pathway alteration in breast cancer and impact of related signature on survival
TLDR
This study is intended to figure out the relationship between the alternation of metabolism and the progression of BC and the mechanism of metabolism alteration remains unclear. Expand
Assessment of the chemotherapeutic potential of a new camptothecin derivative, ZBH-1205.
TLDR
ZBH-1205 was more effective than CPT-11 or SN38 at stabilizing Topo-1-DNA complexes and inducing tumor cell apoptosis and is a promising chemotherapeutic agent to be further assessed in large-scale clinical trials. Expand
PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells
TLDR
The role ofPTEN, but not SHIP and SHIP2, in negatively regulating the PI3K/Akt cascade and in myeloma leukemogenesis is established and the results showed that SHIP, unlike PTEN, did not affect Akt activity in all systems analysed, despite its ability to dephosphorylate aPI3K product. Expand
Co-expression of EGFRvIII with ErbB-2 enhances tumorigenesis: EGFRvIII mediated constitutively activated and sustained signaling pathways, whereas EGF-induced a transient effect on EGFR-mediated
TLDR
It is demonstrated that 29% of DCIS, 40% of primary invasive breast cancers and 54% of metastatic lymph nodes express EGFRvIII by immunohistochemical analysis with two monoclonal antibodies, and that, despite the absence of gene amplification of EGFR in breast carcinoma cells, EG FRvIII was phosphorylated in breast cancer. Expand
Synthesis and Biological Evaluation of Novel 10-Substituted-7-ethyl-10-hydroxycamptothecin (SN-38) Prodrugs
TLDR
Novel prodrugs prepared by conjugating amino acids or dipeptides to the 10-hydroxyl group of SN-38 via a carbamate linkage exhibited the same level of tumor growth inhibitory activity as irinotecan (CPT-11) in a human colon xenograft model in vivo. Expand
ShRNA-mediated silencing of the ubiquitin-specific protease 22 gene restrained cell progression and affected the Akt pathway in nasopharyngeal carcinoma
TLDR
It is suggested that USP22 plays a critical regulatory role in the pathologic processes of NPC, and that it may be a potential biological treatment target in the future. Expand
SEPT9_i1 regulates human breast cancer cell motility through cytoskeletal and RhoA/FAK signaling pathway regulation
TLDR
The expression of SEPT9_i1 positively correlated with paxillin, and both were significantly upregulated in invasive breast cancer tissues of patients with lymph node metastases, suggesting that a mechanism of Septin-9-induced aberrant cancer cell migration is through cytoskeletal regulation and FA modulation. Expand
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