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In this paper we describe the data collection for the TBALL project (Technology Based Assessment of Language and Literacy) and report the results of our efforts. We focus on aspects of our corpus that distinguish it from currently available corpora. The speakers are children (grades K-4), largely non-native speakers of English, and from diverse(More)
Arguably the most important part of automatically assessing a new reader's literacy is in verifying his pronunciation of read-aloud target words. But the pronunciation evaluation task is especially difficult in children, non-native speakers, and pre-literates. Traditional likelihood ratio thresholding methods do not generalize easily, and even expert human(More)
BACKGROUND Schistosomes depend for growth and development on host hormonal signals, which may include the insulin signalling pathway. We cloned and assessed the function of two insulin receptors from Schistosoma japonicum in order to shed light on their role in schistosome biology. METHODOLOGY/PRINCIPAL FINDINGS We isolated, from S. japonicum, insulin(More)
Most speech processing algorithms analyze speech signals frame by frame with a fixed frame rate. Fixed-rate analysis is inconsistent with human speech perception and effectively assigns the same importance or 'weight' to all equi-duration frames. In [1], we proposed a variable frame rate (VFR) analysis technique that is based on a Euclidian distance(More)
When learning to speak English, non-native speakers may pronounce some English phonemes differently from native speakers. These pronunciation variations can degrade an automatic speech recognition system's performance on accented English. This paper is a first attempt to find common pronunciation variations in Spanish-accented English as spoken by young(More)
BACKGROUND AND AIM Chronic hepatitis C virus (HCV) infection is relatively frequent in China. This study investigated the clinical, demographic, and viral and host genetic characteristics that may influence disease manifestations and clinical management. METHODS In this cross-sectional observational study, treatment-naïve Han ethnic adults with recently(More)
Treatment for clinical schistosomiasis has relied centrally on the broad spectrum anthelmintic praziquantel; however, there is limited information on its mode of action or the molecular response of the parasite. This paper presents a transcriptional and functional approach to defining the molecular responses of schistosomes to praziquantel. Differential(More)
This study examines methods for recognizing different classes of phones from accented speech based on voice onset time (VOT). These methods are tested on data from the Tball corpus of Los Angeles-area elementary school children [1]. The methods proposed and tested are: 1) to train models based on standard English VOT contrasts and then extract the VOT(More)
BACKGROUND Cystic hydatid disease (CHD) is a global parasitic zoonosis caused by the dog tapeworm, Echinococcus granulosus. The disease is hyperendemic in western China because of poor economic development; limited community knowledge of CHD; widespread, small-scale household animal production; home killing of livestock; and the feeding of dogs with(More)