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The search for novel anxiolytics devoid of undesirable side-effects typical of classical benzodiazepines (BDZs) has been intense, and flavonoids, as a relative new class of ligands, have been shown to possess anxiolytic effects in vivo. The present study evaluated the pharmacological properties of a naturally occurring monoflavonoid,(More)
Bis(7)-tacrine was previously demonstrated as an antagonist of gamma-aminobutyric acid type A (GABA(A)) receptors. In this study, the effects of a series of alkylene-linked tacrine dimers on GABA(A) receptors were examined. In radioligand binding assay, the analogues differed in binding affinity for GABA(A) receptors, and potency monotonically increased as(More)
The aim of the present study was to evaluate the efficacy and safety of a newly developed robot‑assisted frame-less stereotactic system for deep electrode implantation and radiofrequency thermocoagulation (RFTC). Deep‑electrode implantation was performed in the bilateral mesial temporal lobes of seven patients. Following the implantation of the deep(More)
Seizures may present with ictal or interictal psychosis mimicking primary psychiatric disorders. The authors reviewed EEG, brain-imaging, and clinical data of 240 patients presenting with acute psychotic episode to assess the diagnostic value of EEG in differentiating ictal psychosis from primary psychosis. Seven patients had interictal spikes, but there(More)
BACKGROUND The virtual screening (VS) of lead compounds using molecular docking and pharmacophore detection is now an important tool in drug discovery. VS tasks typically require a combination of several software tools and a molecular graphics system. Thus, the integration of all the requisite tools in a single operating environment could reduce the(More)
The ranking of scores of individual chemicals within a large screening library is a crucial step in virtual screening (VS) for drug discovery. Previous studies showed that the quality of protein-ligand recognition can be improved using spectrum properties and the shape of the binding energy landscape. Here, we investigate whether the energy gap, defined as(More)
In this paper, we consider a highly recursive interconnection network known as the fully connected cubic network (FCCN). By exploiting its recur-sive properties, we thoroughly analyze the performance of a simple routing algorithm for the FCCN. We show that at least 800 of the routes obtained from this simple algorithm are shortest paths, and this percentage(More)
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