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CD38 is critical for social behaviour by regulating oxytocin secretion
It is shown that adult CD38 knockout (CD38-/-) female and male mice show marked defects in maternal nurturing and social behaviour, respectively, with higher locomotor activity and may be an element in neurodevelopmental disorders. Expand
A mechanism for exon skipping caused by nonsense or missense mutations in BRCA1 and other genes
It is shown here that inappropriate exon skipping can be reproduced in vitro, and results from disruption of a splicing enhancer in the coding sequence, arguing against a nuclear reading-frame scanning mechanism for NAS. Expand
Wnt signaling interacts with Shh to regulate taste papilla development
Wnt and Shh signaling pathways are critical for the development and maturation of many epithelial tissues. Both pathways have roles in stem cell maintenance, tissue development, and tumorigenesis.Expand
Exonic Splicing Enhancer Motif Recognized by Human SC35 under Splicing Conditions
Using an in vitro functional selection and amplification procedure, a novel ESE motif recognized by the human SR protein SC35 under splicing conditions is identified and a motif score matrix is generated to help locate SC35-specific enhancers in natural exon sequences. Expand
Cyclopamine and jervine in embryonic rat tongue cultures demonstrate a role for Shh signaling in taste papilla development and patterning: fungiform papillae double in number and form in novel
A prominent role for Shh is demonstrated in fungiform papilla induction and patterning and differences in morphogenetic control of fungiform and circumvallate papilla development and numbers are indicated. Expand
The participation of galanin in pain processing at the spinal level.
It is suggested that upregulation of Galanin in DRG neurones following nerve injury results in antinociception via stimulation of galanin GAL1 receptors on dorsal horn neurones, and that the pro-nociceptive effect of galansin is related to presynaptic galan in GAL2 receptors on primary afferents. Expand
Sonic hedgehog exerts distinct, stage-specific effects on tongue and taste papilla development.
This work immunolocalized the Shh protein and the Patched receptor protein and proposed a model for Shh function at high concentration to form and maintain papillae and, at low concentration, to activate between-papilla genes that maintain a papilla-free epithelium. Expand
Two genetic variants of CD38 in subjects with autism spectrum disorder and controls
The immunohistochemical expression of CD38 in the hypothalamus of post-mortem brains of non-ASD subjects is examined and it is found that CD38 was colocalized with OT in secretory neurons. Expand
Bone morphogenetic proteins and noggin: inhibiting and inducing fungiform taste papilla development.
It is proposed that the BMPs and noggin, colocalized within papilla placodes and the fungiform papillae per se, have opposing inhibitory and activating or inducing roles in papilla development in linear patterns, and a model for these effects is presented. Expand
Development of fungiform papillae: patterned lingual gustatory organs.
Regulatory roles for molecules in several families are presented, and a broad schema is proposed for progressive epithelial differentiation to form taste cell progenitors in parallel with the temporal course, and participation of lingual sensory innervation. Expand