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BACKGROUND Long-term studies of the outcome of very prematurely born infants have clearly documented that the majority of such infants have significant motor, cognitive, and behavioral deficits. However, there is a limited understanding of the nature of the cerebral abnormality underlying these adverse neurologic outcomes. AIM The overall aim of this(More)
This paper presents a pseudo proportional-integral-derivative (PID) tracking control strategy for general non-Gaussian stochastic systems based on a linear B-spline model for the output probability density functions (PDFs). The objective is to control the conditional PDFs of the system output to follow a given target function. Different from existing(More)
In this paper, a minimum entropy control approach for closed-loop tracking error is studied for linear dynamic control systems subjected to stochastic disturbances. The basic idea is to construct a feedback control scheme with the guaranteed closed loop stability using the Youla parameterization that provides a set of free parameters embedded in the(More)
Although suicide in Asia is widely recognized as a compelling problem, obtaining accurate data about suicide in Asia has proved difficult. Some countries make no effort to collect data on the causes of death. In many Asian countries deaths occur without medical certification of the cause and may be reported by family members or other lay people who do not(More)
Developing oligodendrocytes (OLs) are highly vulnerable to excitotoxicity and oxidative stress, both of which are important in the pathogenesis of many brain disorders. OL excitotoxicity is mediated by ionotropic glutamate receptors (iGluRs) of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/kainate type on these cells. Here we report that(More)
Oxidative mechanisms of injury are important in many neurological disorders, including hypoxic-ischemic brain damage. Cerebral palsy after preterm birth is hypothesized to be caused by hypoxic-ischemic injury of developing oligodendrocytes (OLs). Here we examined the developmental sensitivity of OLs to exogenous hydrogen peroxide (H2O2) with stage-specific(More)
Oxidative injury to premyelinating oligodendrocytes (preOLs) in developing white matter has been implicated in the pathogenesis of periventricular leukomalacia, the lesion underlying most cases of cerebral palsy in premature infants. In this study, we investigated the pathways of OL death induced by intracellular glutathione (GSH) depletion. We found that(More)