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The pharmacokinetic profiles of naproxen in blood and synovial fluid (SF) following topical and i.v. bolus administration in dogs, and the local tissue disposition of the drug following topical and oral administration in rats, were investigated to assess the feasibility of topical delivery of naproxen for local and systemic effects. The naproxen gel in(More)
The absorption and disposition of methotrexate (MTX) in the plasma, synovial fluid (SF), skin, and muscle tissue were studied following administration of a topical MTX gel in rabbits and rats. In rabbits, MTX concentrations in the plasma increased steadily toward the peak (5.9 +/- 2.8 ng mL-1) which appeared at approximately 2 h postdose and declined with(More)
Wax microspheres of the hydrophilic drug guaifenesin were prepared by the congealable disperse-phase method using a salting-out procedure. In order to improve the particle properties of the microspheres, adsorbents (colloidal silica, magnesium stearate, and talc) were used during preparation. The effects of adsorbents on microsphere properties such as the(More)
(1) Combinatorial Structure of Finite Frames (S. Narayan): 2012: Kileen Berry, Eric Evert and Sean Nghiem worked on this project in the summer of 2012. This group studied the combinatorial structure of tight frames using factor posets. [A factor poset of a frame is defined to be a collection of subsets of I, the index set of our vectors, ordered by(More)
The effectiveness and mode of action of isopropyl myristate (IPM) as an enhancer for the permeation of naproxen through shed snake skin have been investigated. The highest naproxen permeability was afforded by IPM (36.2 x 10(-4) cm h-1), followed by menthol (25.0 x 10(-4) cm h-1), oleic acid (11.1 x 10(-4) cm h-1), azone (7.3 x 10(-4) cm h-1) and control(More)
For a positive integer m and a subgroup Λ of the unit group (Z/mZ)×, the corresponding generalized Kloosterman sum is the function K(a, b,m,Λ) = ∑ u∈Λ e( au+bu−1 m ). Unlike classical Kloosterman sums, which are real valued, generalized Kloosterman sums display a surprising array of visual features when their values are plotted in the complex plane. In a(More)
Gastric yolk sac tumors are extremely rare with only a few cases reported in the literature. Here, we present the case of a 50-year-old man with an adenocarcinoma and a yolk sac tumor of the stomach, without metastasis to the lymph nodes. The tumor was an early gastric carcinoma confined to the submucosa. Twelve months post-operation the patient was alive(More)
In the recent research era analyzing and classifying images into meaningful categories using low-level visual features and high-level semantic features is a challenging and important problem. This paper focuses on the classification of COREL dataset images into its specific category using Weighted Feature Support Vector Machines (WFSVM) and the results are(More)
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