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The proliferation of large-scale DNA-sequencing projects in recent years has driven a search for alternative methods to reduce time and cost. Here we describe a scalable, highly parallel sequencing system with raw throughput significantly greater than that of state-of-the-art capillary electrophoresis instruments. The apparatus uses a novel fibre-optic(More)
We have produced a draft sequence of the rice genome for the most widely cultivated subspecies in China, Oryza sativa L. ssp. indica, by whole-genome shotgun sequencing. The genome was 466 megabases in size, with an estimated 46,022 to 55,615 genes. Functional coverage in the assembled sequences was 92.0%. About 42.2% of the genome was in exact(More)
A genetic interaction network containing approximately 1000 genes and approximately 4000 interactions was mapped by crossing mutations in 132 different query genes into a set of approximately 4700 viable gene yeast deletion mutants and scoring the double mutant progeny for fitness defects. Network connectivity was predictive of function because interactions(More)
We present the design, implementation, evaluation, and user ex periences of theCenceMe application, which represents the first system that combines the inference of the presence of individuals using off-the-shelf, sensor-enabled mobile phones with sharing of this information through social networking applications such as Facebook and MySpace. We discuss the(More)
Today’s smartphone not only serves as the key computing and communication mobile device of choice, but it also comes with a rich set of embedded sensors, such as an accelerometer, digital compass, gyroscope, GPS, microphone, and camera. Collectively, these sensors are enabling new applications across a wide variety of domains, such as healthcare [1], social(More)
Supporting continuous sensing applications on mobile phones is challenging because of the resource demands of long-term sensing, inference and communication algorithms. We present the design, implementation and evaluation of the <i>Jigsaw continuous sensing engine</i>, which balances the performance needs of the application and the resource demands of(More)
Top end mobile phones include a number of specialized (e.g., accelerometer, compass, GPS) and general purpose sensors (e.g., microphone, camera) that enable new people-centric sensing applications. Perhaps the most ubiquitous and unexploited sensor on mobile phones is the microphone - a powerful sensor that is capable of making sophisticated inferences(More)
Hypermethylation of CpG islands in the promoter regions is an important mechanism to silence the expression of many important genes in cancer. The hypermethylation status is passed to the daughter cells through the methylation of the newly synthesized DNA strand by 5-cytosine DNA methyltransferase (DNMT). We report herein that (-)-epigallocatechin-3-gallate(More)
Stress can have long term adverse effects on individuals' physical and mental well-being. Changes in the speech production process is one of many physiological changes that happen during stress. Microphones, embedded in mobile phones and carried ubiquitously by people, provide the opportunity to continuously and non-invasively monitor stress in real-life(More)
Automatically identifying the person you are talking with using continuous audio sensing has the potential to enable many pervasive computing applications from memory assistance to annotating life logging data. However, a number of challenges, including energy efficiency and training data acquisition, must be addressed before unobtrusive audio sensing is(More)