Tenascin-R (TN-R) is a neural specific protein and an important molecule involved in inhibition of axonal regeneration after spinal cord injury (SCI). Here we report on rabbit-derived TN-R polyclonal antibody, which acts as a TN-R antagonist with high titer and high specificity, promoted neurite outgrowth and sprouting of rat cortical neurons cultured on… (More)
Although human amnion derived mesenchymal stem cells (AMSC) are a promising source of stem cells, their therapeutic potential for traumatic brain injury (TBI) has not been widely investigated. In this study, we evaluated the therapeutic potential of AMSC using a rat TBI model. AMSC were isolated from human amniotic membrane and characterized by flow… (More)
Intracellular sodium (Nai) concentrations rose immediately and progressively during ischemia in the isolated heart. The intracellular double quantum filtered sodium coherence (DQ) intensity also increased during ischemia. However, when normalized for Nai, the DQ intensity began to fall after 40 min of ischemia, and remained depressed during reperfusion.
Although hypoxia and metabolic acidosis have both been shown to impair cardiac function, some workers have suggested that acidosis during a period of hypoxia will actually accelerate physiologic recovery from this insult. To address the interactions of metabolic acidosis and hypoxia further, isolated isovolumic rat hearts were exposed to normal perfusion… (More)
Human amniotic membrane mesenchymal stem cells (hAMSCs) are considered ideal candidate stem cells for cell-based therapy. In this study, we assessed whether hAMSCs transplantation promotes neurological functional recovery in rats after traumatic spinal cord injury (SCI). In addition, the potential mechanisms underlying the possible benefits of this therapy… (More)
Intracellular recording in vivo showed that spontaneous activities of guinea-pig inferior mesenteric ganglion (IMG) neurons were inhibited when any one of the four groups of the nerves connected to the IMG was cutted or blocked, indicating that all the four groups of nerves sent in excitatory input. Colonic and hypogastric nerves convey the peripheral… (More)