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A Nonproton Ligand Sensor in the Acid-Sensing Ion Channel

• Ye Yu, Zhi Chen, +6 authors Tian-le Xu
• Neuron
• 2010

Acid-sensing ion channels (ASICs) have long been considered as extracellular proton (H(+))-gated cation channels, and peripheral ASIC3 channels seem to be a natural sensor of acidic pain. Here, we… (More)

Two disparate ligand-binding sites in the human P2Y1 receptor

• Dong Zhang, Zhan-guo Gao, +16 authors Beili Wu
• Nature
• 2015

In response to adenosine 5′-diphosphate, the P2Y1 receptor (P2Y1R) facilitates platelet aggregation, and thus serves as an important antithrombotic drug target. Here we report the crystal structures… (More)

Possible pathway(s) of metyrapone egress from the active site of cytochrome P450 3A4: a molecular dynamics simulation.

• Weihua Li, Hong Liu, +4 authors Hualiang Jiang
• Drug metabolism and disposition: the biological…
• 2007

To identify a possible pathway(s) for metyrapone egress from the active site of P450 3A4, a 5-ns conventional molecular dynamics simulation followed by steered molecular dynamics simulations was… (More)

Engineering of cytochrome P450 3A4 for enhanced peroxide-mediated substrate oxidation using directed evolution and site-directed mutagenesis.

• Santosh Kumar, Hong Liu, James R. Halpert
• Drug metabolism and disposition: the biological…
• 2006

CYP3A4 has been subjected to random and site-directed mutagenesis to enhance peroxide-supported metabolism of several substrates. Initially, a high-throughput screening method using whole cell… (More)

Genome mining of a prenylated and immunosuppressive polyketide from pathogenic fungi.

• Yit-Heng Chooi, Jinxu Fang, Hong Liu, Scott G. Filler, Pin Wang, Yi Tang
• Organic letters
• 2013

Activation of the polycyclic polyketide prenyltransferase (pcPTase)-containing silent clusters in Aspergillus fumigatus and Neosartorya fischeri led to isolation of a new metabolite neosartoricin… (More)

A new gliotoxin analogue from a marine-derived fungus Aspergillus fumigatus Fres.

• Wen Ying Zhao, Tian Jiao Zhu, +4 authors Qian Qun Gu
• Natural product research
• 2009

A new gliotoxin analogue (1), as well as four known compounds gliotoxin (2), bisdethiobis (methylthio) gliotoxin (3), bis-N-norgliovictin (4) and didehydrobisdethiobis (methylthio) gliotoxin (5),… (More)

Palladium-catalyzed difunctionalization of alkynes via C-N and S-N cleavages: a versatile approach to highly functional indoles.

• Fei Zhao, Dengyou Zhang, Yong Nian, Lei Zhang, Wei Yang, Hong Liu
• Organic letters
• 2014

Palladium-catalyzed intramolecular addition of C-N and S-N bond to alkynes with the migration of functional groups has been achieved. A wide range of functional groups including acyl, pyruvoyl,… (More)

Microwave-assisted rapid synthesis of 2,6,9-substituted purines.

• He Huang, Hong Liu, K. A. Chen, Hualiang Jiang
• Journal of combinatorial chemistry
• 2007

A simple fluorescent receptor selective for Mg2+.

• Yingying Ma, Hong Liu, Shaopu P Liu, Rui Yang
• The Analyst
• 2012

A structurally simple fluorescent receptor (receptor 1) has been synthesized and was found to show a dramatic enhancement in its fluorescence emission upon complexation with Mg(2+). This was maybe… (More)

Cell-permeable iminocoumarine-based fluorescent dyes for mitochondria.

• Diliang Guo, Tao Chen, +5 authors Hong Liu
• Organic letters
• 2011

A class of small molecule fluorophores, 2-iminocoumarin-3-carboxamide derivatives, has been developed by a rapid microwave-assisted process. These fluorescent probes are cell membrane permeable with… (More)

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