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The information of protein targets and small molecule has been highly valued by biomedical and pharmaceutical research. Several protein target databases are available online for FDA-approved drugs as well as the promising precursors that have largely facilitated the mechanistic study and subsequent research for drug discovery. However, those related(More)
The current drug virtual screen (VS) methods mainly include two categories. i.e., ligand/target structure-based virtual screen and that, utilizing protein-ligand interaction fingerprint information based on the large number of complex structures. Since the former one focuses on the one-side information while the later one focuses on the whole complex(More)
Acknowledgment: We thank the Robert Wood Johnson Foundation for funding through the Economic Research Initiative on the Uninsured. We are grateful to Peter Diamond and Jon Gruber for helpful conversations, to Didem Bernard for advice regarding data and to Charlie Brown, Randy Ellis, Albert Ma, Tom McGuire and participants at the ERIU Conference for helpful(More)
With XML becoming the de facto standard for representing and exchanging data on the Internet, the problem of validation of XML data when updated has attracted more and more attentions. The traditional brute-force validation processes the entire updated XML document from scratch, which is less efficient. This paper presents a method for XML incremental(More)
HIV-1 protease is one of the main therapeutic targets in HIV. However, a major problem in treatment of HIV is the rapid emergence of drug-resistant strains. It should be particularly helpful to clinical therapy of AIDS if one method can be used to predict antivirus capability of compounds for different variants. In our study, proteochemometric (PCM) models(More)
BACKGROUND Herbal medicine has long been viewed as a valuable asset for potential new drug discovery and herbal ingredients' metabolites, especially the in vivo metabolites were often found to gain better pharmacological, pharmacokinetic and even better safety profiles compared to their parent compounds. However, these herbal metabolite information is still(More)
Traditional Chinese Medicine (TCM) treatment has been commonly used to treat Chronic Hepatitis B (CHB) in Asian countries based on TCM syndrome diagnosis, also called "ZHENG". The syndrome is identified through the four-diagnostic methods, with certain degree of subjectivity and ambiguity from individual doctors. Normally those CHB patients also receive(More)
This paper designs and develops an Asia sovereign debt crises predictive model based on support vector machine. A three year time window is defined to observe debt crises probability. Taking 173 samples from eighteen emerging market countries in Asia, the empirical work reveals that the model can predict sovereign debt crises in next three years with(More)
OBJECTIVES Massive hemoptysis is a major clinical problem associated with high morbidity and mortality. Transcatheter arterial embolization is widely used for the treatment of massive hemoptysis, but it was reported that the recurrence rate after embolization is 12-54% in the previous studies. We evaluated the therapeutic effect of transcatheter arterial(More)