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Natural anti-HIV agents-part I: (+)-demethoxyepiexcelsin and verticillatol from Litsea verticillata.
The eudesmane sesquiterpenoid, verticillatol, as well as the lignan, (+)-5'-demethoxyepiexcelsin, and a known lignans, were isolated from Litsea Verticillata Hance and the absolute configuration of the new sesQuiterpenoids was determined by the generation of Mosher esters. Expand
Miliusanes, a class of cytotoxic agents from Miliusa sinensis.
Bioassay-directed fractionation of the leaves, twigs, and flowers of Miliusa sinensis Finet and Gagnep. (Annonaceae) led to the isolation of a new class of potential anticancer lead molecules. TheyExpand
A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition
Curcumin derivative C1 is identified as a novel MTOR-independent activator of TFEB, which enhances autophagy and lysosome biogenesis in vitro and in vivo and is a potential therapeutic agent for the treatment of neurodegenerative diseases. Expand
Anti-tuberculosis constituents from the stem bark of Micromelum hirsutum.
Anti-TB bioassay-directed fractionation led to the isolation of six carbazole alkaloids, as well as the gamma-lactone derivative of oleic acid, from the stem bark of Micromelum hirsutum, which appears worthy of further evaluation as a potential new anti-TB agent. Expand
Bioactive dammarane triterpenes from the mangrove plant Bruguiera gymnorrhiza.
Three new dammarane triterpenes, bruguierins A-C (1-3), were isolated from a petroleum ether extract of the flowers of Bruguiera gymnorrhiza. Their structures were determined on the basis of physicalExpand
Rourinoside and rouremin, antimalarial constituents from Rourea minor.
Bioassay-directed fractionation of the antimalarial active CHCl(3) extract of the dried stems of Rourea minor (Gaertn.) Aubl. (Connaraceae) liana led to isolation of two glycosides, rourinoside (1)Expand
Anti-HIV diphyllin glycosides from Justicia gendarussa.
In a search for new anti-HIV active leads from over several thousands of plant extracts, a potent plant lead is identified as Justicia gendarussa (Acanthaceae), a medicinal plant that has been used for the treatment of injury, arthritis and rheumatism in Asia. Expand
Strong axiality and Ising exchange interaction suppress zero-field tunneling of magnetization of an asymmetric Dy2 single-molecule magnet.
The high axiality and Ising exchange interaction efficiently suppress quantum tunneling of magnetization of an asymmetric dinuclear Dy(III) complex, as revealed by combined experimental andExpand
Chemical constituents from Amentotaxus yunnanensis and Torreyayunnanensis.
The presence of the amentoflavone biflavonoids (1, 3-5) in A. yunnanensis supports its placement in the Taxaceae and suggests that these two genera are closely related. Expand
New Sesquiterpenes from Litsea verticillata.
Isolates 1, 4, and 12 were found to inhibit HIV-1 replication in a green fluorescent protein (GFP)-based reporter cell line (HOG) with IC(50) values of 6.5 (27.5), 17.4 (73.1), and 28.0 (119.7) microg/mL (microM), respectively. Expand