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Multi-criteria evaluation (MCE) is perhaps the most fundamental of decision support operations in geographical information systems (GIS). This paper reviews two main MCE approaches employed in GIS, namely Boolean and Weighted Linear Combination (WLC), and discusses issues and problems associated with both. To resolve the conceptual di erences between the(More)
Based on the classic augmented Lagrangian multiplier method, we propose , analyze and test an algorithm for solving a class of equality-constrained non-smooth optimization problems (chiefly but not necessarily convex programs) with a particular structure. The algorithm effectively combines an alternating direction technique with a nonmonotone line search to(More)
In myotonic dystrophy (dystrophia myotonica, DM), expression of RNAs that contain expanded CUG or CCUG repeats is associated with degeneration and repetitive action potentials (myotonia) in skeletal muscle. Using skeletal muscle from a transgenic mouse model of DM, we show that expression of expanded CUG repeats reduces the transmembrane chloride(More)
With the development of the NAND-Flash technology, NAND-Flash based Solid-State Disk (SSD) has been attracting a great deal of attention from both industry and academia. While a range of SSD research topics, from interface techniques to buffer management and Flash Translation Layer (FTL), from performance to endurance and energy efficiency, have been(More)
This paper considers the self-stabilizing leader-election problem in a model of interacting anonymous finite-state agents. Leader election is a fundamental problem in distributed systems; many distributed problems are easily solved with the help of a central coordinator. Self-stabilizing algorithms do not require initialization in order to operate correctly(More)
Myotonic dystrophy type 1 (DM1) is caused by expansion of a CTG repeat in the DMPK gene. In skeletal muscles, DM1 may involve a novel, RNA-dominant disease mechanism in which transcripts from the mutant DMPK allele accumulate in the nucleus and compromise the regulation of alternative splicing. Here we show evidence for a similar disease mechanism in brain.(More)
In this millennium, global drylands face a myriad of problems that present tough research, management, and policy challenges. Recent advances in dryland development, however, together with the integrative approaches of global change and sustainability science, suggest that concerns about land degradation, poverty, safeguarding biodiversity, and protecting(More)
Paroxysmal kinesigenic dyskinesias is a paroxysmal movement disorder characterized by recurrent, brief attacks of abnormal involuntary movements induced by sudden voluntary movements. Although several loci, including the pericentromeric region of chromosome 16, have been linked to paroxysmal kinesigenic dyskinesias, the causative gene has not yet been(More)
Fault tolerance is an essential requirement for real-time systems, due to the potentially catastrophic consequences of faults. In this paper, we investigate an efficient off-line scheduling algorithm in which real-time tasks with precedence constraints can tolerate one processor's permanent failure in a heterogeneous system with fully connected network. The(More)